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After stroke onset, ischemia, hypoxia, infiltration of blood components into the brain parenchyma, and lysed cell fragments, among other factors, invariably increase blood\u2013brain barrier (BBB) permeability, the inflammatory response, and brain edema. These changes lead to neuronal cell death and synaptic dysfunction, the latter of which poses a significant challenge to stroke treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Synaptic dysfunction occurs in various ways after stroke and includes the following: damage to neuronal structures, accumulation of pathologic proteins in the cell body, decreased fluidity and release of synaptic vesicles, disruption of mitochondrial transport in synapses, activation of synaptic phagocytosis by microglia\/macrophages and astrocytes, and a reduction in synapse formation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This review summarizes the cellular and molecular mechanisms related to synapses and the protective effects of drugs or compounds and rehabilitation therapy on synapses in stroke according to recent research. Such an exploration will help to elucidate the relationship between stroke and synaptic damage and provide new insights into protecting synapses and restoring neurologic function.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.14744","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T12:59:30Z","timestamp":1715345970000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Current evidence of synaptic dysfunction after stroke: Cellular and molecular mechanisms"],"prefix":"10.1111","volume":"30","author":[{"given":"Chuan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory Affiliated Hospital of Jiujiang University  Jiujiang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Jiang","sequence":"additional","affiliation":[{"name":"Jiujiang Clinical Precision Medicine Research Center  Jiujiang Jiangxi 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