{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:01:17Z","timestamp":1792598477655,"version":"4.5.0"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:00:00Z","timestamp":1716336000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201432"],"award-info":[{"award-number":["82201432"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin Municipality","doi-asserted-by":"publisher","award":["19JCYBJC27500"],"award-info":[{"award-number":["19JCYBJC27500"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to unravel the dehydration status of patients with cerebral venous sinus thrombosis (CVST) to facilitate the understanding of dehydration in CVST.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a multicenter retrospective study and three populations were recruited, namely, patients with CVST, CVST mimics, and healthy subjects. Blood samples were obtained 1\u20132\u2009days after admission to assess dehydration status. Stata 15.1 was performed for statistical analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 208 patients were diagnosed with CVST, 237 with CVST mimics, and 200 healthy individuals were enrolled. The urine specific gravity (USG, 1.020 [1.014, 1.029] vs. 1.017 [1.011, 1.021]) was higher in patients with CVST than in those with mimics (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The percentage of USG &gt;1.03 was also higher in CVST (22.6%) than in its mimics (6.3%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). With the development of CVST, USG (acute vs. sub\u2010acute vs. chronic, 1.022 [1.015, 1.033] vs. 1.021 [1.015, 1.031] vs. 1.019 [1.014, 1.025]) decreased. All dehydration\u2010related markers could not differentiate CVST from its mimics and healthy populations, and they were not associated with CVST severity and prognosis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>High levels of USG, especially USG &gt;1.013, were more common in patients with CVST. Dehydration\u2010related indices could not characterize CVST and were not associated with CVST severity and prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.14760","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T06:20:44Z","timestamp":1716358844000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Dehydration in cerebral venous sinus thrombosis"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3562-2187","authenticated-orcid":false,"given":"Jiayue","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Neurology Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duo","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology Tianjin Huanhu Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Neurology Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobing","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Neurology Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangyuan","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Neurology Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanye","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Neurology Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Neurology Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8452-8758","authenticated-orcid":false,"given":"Ran","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/2396987317719364"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0b013e31820a8364"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2019.105384"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12034"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hch050"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(85)90693-6"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-018-8799-6"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2019.11.002"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2009.12.019"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.011369"},{"key":"e_1_2_9_12_1","first-page":"1739","article-title":"Normal structures in the intracranial dural sinuses: delineation with 3D contrast\u2010enhanced magnetization prepared rapid acquisition gradient\u2010echo imaging sequence","volume":"23","author":"Liang L","year":"2002","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2020.0404"},{"issue":"79","key":"e_1_2_9_14_1","first-page":"1487","article-title":"Dehydration reduces cardiac output and increases systemic and cutaneous vascular resistance during exercise","volume":"1995","author":"Gonz\u00e1lez\u2010Alonso J","year":"1985","journal-title":"J Appl Physiol"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12841"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000000419"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpf.12690"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2648.2011.05645.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2017.06.044"}],"container-title":["CNS Neuroscience &amp; 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