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Of them, 76 patients from Huashan Hospital were included in the derivation cohort to develop the predictive nomogram, which was externally validated using 32 patients from Tangdu Hospital. The clinical response is defined as a\u2009\u2265\u20093 points decrease in QMG score within 6\u2009months. Both clinical and genetic characteristics were included to screen predictors via multivariate logistic regression. Discrimination and calibration were measured by the area under the receiver operating characteristic curve (AUC\u2010ROC) and Hosmer\u2013Lemeshow test, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Disease duration (OR\u2009=\u20090.987, <jats:italic>p<\/jats:italic>\u2009=\u20090.032), positive anti\u2010muscle\u2010specific tyrosine kinase antibodies (OR\u2009=\u200919.8, <jats:italic>p<\/jats:italic>\u2009=\u20090.007), and genotypes in <jats:italic>FCGR2A<\/jats:italic> rs1801274 (AG: OR\u2009=\u20090.131, <jats:italic>p<\/jats:italic>\u2009=\u20090.024;GG:OR\u2009=\u20090.037, <jats:italic>p<\/jats:italic>\u2009=\u20090.010) were independently associated with clinical response of post\u2010rituximab patients. The nomogram identified MG patients with clinical response with an AUC\u2010ROC (95% CI) of 0.875 (0.798\u20130.952) in the derivation cohort and 0.741(0.501\u20130.982) in the validation cohort. Hosmer\u2013Lemeshow test showed a good calibration (derivation: Chi\u2010square\u2009=\u20093.181, <jats:italic>p<\/jats:italic>\u2009=\u20090.923; validation: Chi\u2010square\u2009=\u20098.098, <jats:italic>p<\/jats:italic>\u2009=\u20090.424).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The nomogram achieved an optimal prediction of short\u2010term outcomes in patients treated with low\u2010dose rituximab.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.14761","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:13:45Z","timestamp":1715609625000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A predictive nomogram for short\u2010term outcomes of myasthenia gravis patients treated with low\u2010dose 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