{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T16:06:40Z","timestamp":1778170000329,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T00:00:00Z","timestamp":1718150400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017501","name":"Science-Health Joint Medical Scientific Research Project of Chongqing","doi-asserted-by":"publisher","award":["2023GGXM003"],"award-info":[{"award-number":["2023GGXM003"]}],"id":[{"id":"10.13039\/100017501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873754"],"award-info":[{"award-number":["81873754"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371333"],"award-info":[{"award-number":["82371333"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>The extent of perihematomal edema following intracerebral hemorrhage (ICH) significantly impacts patient prognosis, and disruption of the blood\u2013brain barrier (BBB) exacerbates perihematomal edema. However, the role of peripheral IL\u201010 in mitigating BBB disruption through pathways that link peripheral and central nervous system signals remains poorly understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Recombinant IL\u201010 was administered to ICH model mice via caudal vein injection, an IL\u201010\u2010inhibiting adeno\u2010associated virus and an IL\u201010 receptor knockout plasmid were delivered intraventricularly, and neurobehavioral deficits, perihematomal edema, BBB disruption, and the expression of JAK1 and STAT3 were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our study demonstrated that the peripheral cytokine IL\u201010 mitigated BBB breakdown, perihematomal edema, and neurobehavioral deficits after ICH and that IL\u201010 deficiency reversed these effects, likely through the IL\u201010R\/JAK1\/STAT3 signaling pathway.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Peripheral IL\u201010 has the potential to reduce BBB damage and perihematomal edema following ICH and improve patient prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.14796","type":"journal-article","created":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T04:43:23Z","timestamp":1718253803000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Peripheral cytokine interleukin\u201010 alleviates perihematomal edema after intracerebral hemorrhage via interleukin\u201010 receptor\/<scp>JAK1<\/scp>\/<scp>STAT3<\/scp> signaling"],"prefix":"10.1111","volume":"30","author":[{"given":"Yao","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Neurosurgery and State Key Laboratory of Trauma and Chemical Poisoning, Southwest Hospital Third Military Medical University (Army Medical University)  Chongqing China"},{"name":"Chongqing Key Laboratory of Intelligent Diagnosis, Treatment and Rehabilitation of Central Nervous System Injuries, Southwest Hospital Third Military Medical University (Army Medical University)  Chongqing China"},{"name":"Chongqing Clinical Research Center for Neurosurgery, Southwest Hospital Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaishan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and State Key Laboratory of Trauma and Chemical Poisoning, Southwest Hospital Third Military Medical University (Army Medical University)  Chongqing China"},{"name":"Chongqing Key Laboratory of Intelligent Diagnosis, Treatment and Rehabilitation of Central Nervous System Injuries, Southwest Hospital Third Military Medical University (Army Medical University)  Chongqing China"},{"name":"Chongqing Clinical Research Center for Neurosurgery, Southwest Hospital Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yalan","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and State Key Laboratory of Trauma and Chemical Poisoning, Southwest Hospital Third Military Medical University (Army Medical University)  Chongqing China"},{"name":"Chongqing Key Laboratory of Intelligent Diagnosis, Treatment and Rehabilitation of Central Nervous System Injuries, Southwest Hospital Third Military Medical University (Army Medical University)  Chongqing China"},{"name":"Chongqing Clinical Research Center for Neurosurgery, Southwest Hospital Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and State Key Laboratory of Trauma and Chemical Poisoning, Southwest Hospital Third Military Medical University (Army Medical University)  Chongqing China"},{"name":"Chongqing Key Laboratory of Intelligent Diagnosis, Treatment and Rehabilitation of Central Nervous System Injuries, Southwest Hospital Third Military Medical University (Army Medical University)  Chongqing China"},{"name":"Chongqing Clinical Research Center for Neurosurgery, Southwest Hospital Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xufang","family":"Ru","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and State Key Laboratory of Trauma and Chemical Poisoning, Southwest Hospital Third Military Medical University (Army Medical University)  Chongqing China"},{"name":"Chongqing Key Laboratory of Intelligent Diagnosis, Treatment and Rehabilitation of Central Nervous System Injuries, Southwest Hospital Third Military Medical University (Army Medical University)  Chongqing China"},{"name":"Chongqing Clinical Research Center for Neurosurgery, Southwest Hospital Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenyan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and State Key Laboratory of Trauma and Chemical Poisoning, Southwest Hospital Third Military Medical University (Army Medical University)  Chongqing China"},{"name":"Chongqing Key Laboratory of Intelligent Diagnosis, Treatment and Rehabilitation of Central Nervous System Injuries, Southwest Hospital Third Military Medical University (Army Medical University)  Chongqing China"},{"name":"Chongqing Clinical Research Center for Neurosurgery, Southwest Hospital Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and State Key Laboratory of Trauma and Chemical Poisoning, Southwest Hospital Third Military Medical University (Army Medical University)  Chongqing China"},{"name":"Chongqing Key Laboratory of Intelligent Diagnosis, Treatment and Rehabilitation of Central Nervous System Injuries, Southwest Hospital Third Military Medical University (Army Medical University)  Chongqing China"},{"name":"Chongqing Clinical Research Center for Neurosurgery, Southwest Hospital Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and State Key Laboratory of Trauma and Chemical Poisoning, Southwest Hospital Third Military Medical University (Army Medical University)  Chongqing China"},{"name":"Chongqing Key Laboratory of Intelligent Diagnosis, Treatment and Rehabilitation of Central Nervous System Injuries, Southwest Hospital Third Military Medical University (Army Medical University)  Chongqing China"},{"name":"Chongqing Clinical Research Center for Neurosurgery, Southwest Hospital Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2270-8822","authenticated-orcid":false,"given":"Qin","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Ren Ji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9905-9138","authenticated-orcid":false,"given":"Yujie","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and State Key Laboratory of Trauma and Chemical Poisoning, Southwest Hospital Third Military Medical University (Army Medical University)  Chongqing China"},{"name":"Chongqing Key Laboratory of Intelligent Diagnosis, Treatment and Rehabilitation of Central Nervous System Injuries, Southwest Hospital Third Military Medical University (Army Medical University)  Chongqing China"},{"name":"Chongqing Clinical Research Center for Neurosurgery, Southwest Hospital Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(24)00038-3"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2019.03.003"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2201449"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2021.02.001"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201901024RR"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0113043"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000027211.73567.fa"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.353495"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2023.122277"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-022-00305-3"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-53263-6"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/15459683241233261"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-1699-6"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-023-00955-9"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30364-1"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2022.105948"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201902478R"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-023-01521-1"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X231214838"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102982"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-013-2294-3"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1188750"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2018.00458"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2017.07.017"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.03-0534"}],"container-title":["CNS Neuroscience &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cns.14796","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T04:17:22Z","timestamp":1721017042000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cns.14796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/cns.14796"],"URL":"https:\/\/doi.org\/10.1111\/cns.14796","archive":["Portico"],"relation":{},"ISSN":["1755-5930","1755-5949"],"issn-type":[{"value":"1755-5930","type":"print"},{"value":"1755-5949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"2024-04-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14796"}}