{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T08:55:42Z","timestamp":1790326542082,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005089","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["7113155"],"award-info":[{"award-number":["7113155"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81271556"],"award-info":[{"award-number":["81271556"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871339"],"award-info":[{"award-number":["81871339"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To study the changes in cortical thickness and subcortical gray matter structures in children with complete spinal cord injury (CSCI), reveal the possible causes of dysfunction beyond sensory motor dysfunction after CSCI, and provide a possible neural basis for corresponding functional intervention training.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010seven pediatric CSCI patients and 34 age\u2010, gender\u2010matched healthy children as healthy controls (HCs) were recruited. The 3D high\u2010resolution T1\u2010weighted structural images of all subjects were obtained using a 3.0 Tesla MRI system. Statistical differences between pediatric CSCI patients and HCs in cortical thickness and volumes of subcortical gray matter structures were evaluated. Then, correlation analyses were performed to analyze the correlation between the imaging indicators and clinical characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with HCs, pediatric CSCI patients showed decreased cortical thickness in the right precentral gyrus, superior temporal gyrus, and posterior segment of the lateral sulcus, while increased cortical thickness in the right lingual gyrus and inferior occipital gyrus. The volume of the right thalamus in pediatric CSCI patients was significantly smaller than that in HCs. No significant correlation was found between the imaging indicators and the injury duration, sensory scores, and motor scores of pediatric CSCI patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings demonstrated that the brain structural reorganizations of pediatric CSCI occurred not only in sensory motor areas but also in cognitive and visual related brain regions, which may suggest that the visual processing, cognitive abnormalities, and related early intervention therapy also deserve greater attention beyond sensory motor rehabilitation training in pediatric CSCI patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.14810","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T07:40:52Z","timestamp":1718696452000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Alterations in cortical thickness and volumes of subcortical structures in pediatric patients with complete spinal cord injury"],"prefix":"10.1111","volume":"30","author":[{"given":"Ling","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beining","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3410-6773","authenticated-orcid":false,"given":"Weimin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Chaoyang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengfei","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Affiliated Hospital of Hebei Engineering University  Handan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5210-9647","authenticated-orcid":false,"given":"Qian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jubao","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Xuanwu Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0425-3921","authenticated-orcid":false,"given":"Jie","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baowei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Affiliated Hospital of Hebei Engineering University  Handan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0822-125X","authenticated-orcid":false,"given":"Nan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2022.101080"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2017.02064"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhu027"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2018.07.474"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.10.005"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3302-16.2017"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.11.012"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2020.19030331"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2022.08.023"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsab047"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0000000000004030"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.46292\/sci21-00046"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23163"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A7847"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.021"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2004.09.008"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.102"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2614-20.2021"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2022.105674"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31823fcd9c"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2015.01.014"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402680101"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.01296"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/87565640701190841"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2023.1084443"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.06.010"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2023.120217"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhz126"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1037\/dev0000716"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2021.04.050"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-20049-1"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2014.02.024"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhab016"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.visres.2014.12.024"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-96876-6"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11247447"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.2307\/1130258"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12984-020-0654-1"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1435808"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nss113"}],"container-title":["CNS Neuroscience &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cns.14810","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T04:17:49Z","timestamp":1721017069000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cns.14810"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/cns.14810"],"URL":"https:\/\/doi.org\/10.1111\/cns.14810","archive":["Portico"],"relation":{},"ISSN":["1755-5930","1755-5949"],"issn-type":[{"value":"1755-5930","type":"print"},{"value":"1755-5949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"2023-11-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14810"}}