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Logistic regression and multiple linear regression were used for producing combined indicators and prognostic assessment, respectively, including <jats:italic>A&amp;T, A&amp;N, T&amp;N, A&amp;T&amp;N<\/jats:italic>, etc.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Combined diagnostic indicator with <jats:italic>A&amp;T&amp;N<\/jats:italic> had the potential for differentiating AE from other types of RPDs, identifying 62.51% and 75% of AE subjects based on CSF and serum samples, respectively, compared to 39.13% and 37.5% when using autoantibodies. CSF t\u2010Tau was associated with survival in the CJD group (adjusted <jats:italic>R<\/jats:italic>\u2010Square\u2009=\u20090.16, <jats:italic>p<\/jats:italic>\u2009=\u20090.02), and its prognosis value improved when using combined predictors based on the ATN framework (adjusted <jats:italic>R<\/jats:italic>\u2010Square\u2009=\u20090.273, <jats:italic>p<\/jats:italic>\u2009=\u20090.014).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Combined indicators based on the ATN framework provide a novel perspective for establishing biomarkers for early recognition of RPDs due to treatment\u2010responsive causes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.14857","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T03:23:53Z","timestamp":1721186633000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Novel diagnostic and prognostic approach for rapidly progressive dementias: Indicators based on amyloid\/tau\/neurodegeneration (<scp>ATN<\/scp>) framework"],"prefix":"10.1111","volume":"30","author":[{"given":"Yuan","family":"Cheng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College Fudan University  Shanghai China"},{"name":"National Center for Neurological Disorders  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu\u2010Fen","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College Fudan University  Shanghai China"},{"name":"National Center for Neurological Disorders  Shanghai 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