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This study aimed to investigate the static, dynamic, topological and organizational changes in functional brain network induced by five clinically\u2010used general anesthetics in the rat brain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Male Sprague\u2013Dawley rats (<jats:italic>n<\/jats:italic>\u2009=\u200957) were randomly allocated to received propofol, isoflurane, ketamine, dexmedetomidine, or combined isoflurane plus dexmedetomidine anesthesia. Resting\u2010state functional magnetic resonance images were acquired under general anesthesia and analyzed for changes in dynamic functional brain networks compared to the awake state.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Different general anesthetics induced distinct patterns of functional connectivity inhibition within brain\u2010wide networks, resulting in multi\u2010level network reorganization primarily by impairing the functional connectivity of cortico\u2010subcortical networks as well as by reducing information transmission capacity, intrinsic connectivity, and network architecture stability of subcortical regions. Conversely, functional connectivity and topological properties were preserved within cortico\u2010cortical networks, albeit with fewer dynamic fluctuations under general anesthesia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings highlighted the effects of different general anesthetics on functional brain network reorganization, which might shed light on the drug\u2010invariant mechanism of anesthetic\u2010induced unconsciousness.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.14866","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T03:26:49Z","timestamp":1721186809000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Common functional mechanisms underlying dynamic brain network changes across five general anesthetics: A rat <scp>fMRI<\/scp> 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