{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T03:57:07Z","timestamp":1779249427892,"version":"3.51.4"},"reference-count":58,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,7,28]],"date-time":"2024-07-28T00:00:00Z","timestamp":1722124800000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971233"],"award-info":[{"award-number":["81971233"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Angiogenesis is crucial in neuroprotection of secondary thalamic injury after cortical infarction. The p75 neurotrophin receptor (p75<jats:sup>NTR<\/jats:sup>) plays a key role in activating angiogenesis. However, the effects of p75<jats:sup>NTR<\/jats:sup> on angiogenesis in the thalamus after cortical infarction are largely unknown. Herein we investigate whether p75<jats:sup>NTR<\/jats:sup> facilitates angiogenesis to attenuate secondary thalamic damage via activating hypoxia\u2010inducible factor 1\u03b1 (HIF\u20101\u03b1)\/vascular endothelial growth factor (VEGF) pathway mediated by Von Hippel\u2013Lindau (VHL) after distal middle cerebral artery occlusion (dMCAO).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The male rat model of dMCAO was established. The effects of p75<jats:sup>NTR<\/jats:sup> on the angiogenesis was evaluated using RNA\u2010sequencing, immunohistochemistry, western blot, quantitative real\u2010time polymerase chain reaction, magnetic resonance imaging, behavior tests, viral and pharmacological interventions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that the p75<jats:sup>NTR<\/jats:sup> and vessel density were decreased in ipsilateral thalamus after dMCAO. The p75<jats:sup>NTR<\/jats:sup>\u2010VHL interaction was reduced, which promoted the ubiquitination degradation of HIF\u20101\u03b1 and reduced VEGF expression after dMCAO. Notably, p75<jats:sup>NTR<\/jats:sup> overexpression restrained the ubiquitination degradation of HIF\u20101\u03b1 by inhibiting VHL\u2010HIF\u20101\u03b1 interaction, further promoted angiogenesis, increased cerebral blood flow of ipsilateral thalamus and improved neurological function after dMCAO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>For the first time, we highlighted that the enhancement of p75<jats:sup>NTR<\/jats:sup>\u2010VHL interaction promoted angiogenesis in attenuating secondary thalamic damage after dMCAO.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.14875","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T04:49:19Z","timestamp":1722228559000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The p75 neurotrophin receptor attenuates secondary thalamic damage after cortical infarction by promoting angiogenesis"],"prefix":"10.1111","volume":"30","author":[{"given":"Linhui","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Neurology, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, The Second Affiliated Hospital Guangzhou Medical University  Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kongping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, The Second Affiliated Hospital Guangzhou Medical University  Guangzhou Guangdong China"},{"name":"Department of Neurology The Affiliated Brain Hospital, Guangzhou Medical University  Guangzhou Guangdong 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