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Previous studies have proven that melatonin could improve memory loss, but its specific mechanism is still confused.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this study, we used in\u00a0vivo and in\u00a0vitro models to examine the neuroprotective effect of melatonin on scopolamine (SCOP)\u2010induced cognitive dysfunction. The behavioral tests were performed.\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010FDG PET imaging was used to assess the metabolism of the brain. Protein expressions were determined through kit detection, Western blot, and immunofluorescence. Nissl staining was conducted to reflect neurodegeneration. MTT assay and RNAi transfection were applied to perform the in\u00a0vitro experiments.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We found that melatonin could ameliorate SCOP\u2010induced cognitive dysfunction and relieve anxious\u2010like behaviors or HT22 cell damage.\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010FDG PET\u2010CT results showed that melatonin could improve cerebral glucose uptake in SCOP\u2010treated mice. Melatonin restored the cholinergic function, increased the expressions of neurotrophic factors, and ameliorated oxidative stress in the brain of SCOP\u2010treated mice. In addition, melatonin upregulated the expression of silent information regulator 1 (SIRT1), which further relieved endoplasmic reticulum (ER) stress by decreasing the expression of phosphorylate inositol\u2010requiring enzyme (p\u2010IRE1\u03b1) and its downstream, X\u2010box binding protein 1 (XBP1).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results indicated that melatonin could ameliorate SCOP\u2010induced cognitive dysfunction through the SIRT1\/IRE1\u03b1\/XBP1 pathway. SIRT1 might be the critical target of melatonin in the treatment of dementia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.14891","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T06:10:52Z","timestamp":1721974252000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Melatonin attenuates scopolamine\u2010induced cognitive dysfunction through SIRT1\/IRE1\u03b1\/XBP1 pathway"],"prefix":"10.1111","volume":"30","author":[{"given":"Xiao\u2010Qi","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Traditional Chinese Medicine Syndrome The Second Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"},{"name":"Department of Neurology The Second Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"},{"name":"Department of Neurology Guangdong Provincial Hospital of Chinese Medicine  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