{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:15:57Z","timestamp":1789038957578,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,4]],"date-time":"2024-08-04T00:00:00Z","timestamp":1722729600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171231"],"award-info":[{"award-number":["82171231"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>PD\u20101 block was reported to impair opioid\u2010induced antinociception and affect cognitive function in rodents and non\u2010human primates. This prospective multicenter cohort study aims to investigate the possible impact of neoadjuvant immunotherapy with PD\u20101 antibody on perioperative analgesic effect of opioids and postoperative delirium (POD) for non\u2010small\u2010cell lung cancer (NSCLC) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eighty\u2010four NSCLC patients from three medical centers with neoadjuvant chemoimmunotherapy (nCIT) or chemotherapy (nCT) were enrolled. The primary outcome is the total perioperative opioid consumption defined as the sum of intraoperative and postoperative opioid use within 3\u2009days after surgery. Secondary outcomes compromise of incidence of POD, pain intensity, and number of analgesic pump press. Tumor prognostic parameters and perioperative change of inflammatory cytokines and soluble PD\u2010L1 level were also recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty\u2010one patients were included in the final analysis. The total opioid consumption (sufentanil equivalent) perioperatively in the nCIT group was significantly higher than that in the nCT group, with mean difference of 60.39\u2009\u03bcg, 95% CI (25.58\u201395.19),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001. Multiple linear regression analysis showed that nCIT was correlated with increased total opioid consumption (\u03b2\u2009=\u20090.305; 95% CI, 0.152\u20130.459;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The incidence of moderate\u2010to\u2010severe pain and cumulative analgesic pump press within 72\u2009h was significantly higher in subjects with nCIT. There is no statistical difference in incidence of POD between groups within 72\u2009h after surgery. The pathologic complete response rate and perioperative serum IL\u20106 level were higher in the nCIT group than in the nCT group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with NSCLC receiving nCIT warrant increased opioid consumption perioperatively and suffered from more postoperative pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial Registration<\/jats:title>\n                    <jats:p>NCT05273827.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.14893","type":"journal-article","created":{"date-parts":[[2024,8,4]],"date-time":"2024-08-04T12:53:16Z","timestamp":1722775996000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Increased opioid consumption in neoadjuvant immunotherapy plus chemotherapy for patients with non\u2010small\u2010cell lung cancer: A multicenter, prospective cohort study"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8374-6427","authenticated-orcid":false,"given":"Kaiyuan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin's Clinical Research Center for Cancer  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxu","family":"Er","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Tianjin University Chest Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin's Clinical Research Center for Cancer  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengcheng","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8303-8690","authenticated-orcid":false,"given":"Yang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruifang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Tianjin University Chest Hospital  Tianjin 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