{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T20:40:39Z","timestamp":1791664839182,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:00:00Z","timestamp":1722902400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870890"],"award-info":[{"award-number":["81870890"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Deep brain stimulation (DBS) is not routinely performed in elderly patients (\u226575\u2009years old) to date because of concerns about complications and decreased benefit. This study aimed to evaluate the safety and efficacy of DBS in elderly patients with Parkinson's disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis was performed using data from 40 elderly patients from four centers who were treated with neurosurgical robot\u2010assisted DBS between September 2016 and December 2021. These patients were followed up for a minimum period of 2\u2009years, with a subgroup of nine patients followed up for 5\u20137\u2009years. Patient demographic characteristics, surgical information, pre\u2010 and postoperative motor scores, non\u2010motor scores, activities of daily living, and complications were retrospectively analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean surgical procedure duration was 1.65\u2009\u00b1\u20090.24\u2009h, with a mean electrode implantation duration of 1.10\u2009\u00b1\u20090.23\u2009h and a mean pulse generator implantation duration of 0.55\u2009\u00b1\u20090.07\u2009h. The mean pneumocephalus volume, electrode fusion error, and Tao's DBS surgery scale were 16.23\u2009\u00b1\u200912.81\u2009cm\n                      <jats:sup>3<\/jats:sup>\n                      , 0.81\u2009\u00b1\u20090.23\u2009mm, and 77.63\u2009\u00b1\u20098.08, respectively. One patient developed a skin infection, and the device was removed. The Unified Parkinson's disease rating scale, Unified Parkinson's disease rating scale of Part III, tremor, rigidity, bradykinesia, axial, and Barthel index for activities of daily living (ADL\u2010Barthel) scores significantly improved at the 2\u2010year follow\u2010up (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). The levodopa equivalent daily dose (LEDD) was significantly reduced at the 2\u2010year follow\u2010up (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). However, the Montreal cognitive assessment, Hamilton depression scale, and Hamilton anxiety scale scores did not significantly change during the 2\u2010year follow\u2010up (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). Additionally, in the subgroup with a 5\u2010year follow\u2010up, the motor symptoms, ADL\u2010Barthel score, and cognitive function worsened over time compared to baseline. However, there was still an improvement in motor symptoms and ADL with DBS on\u2010stimulation compared with the off\u2010stimulation state. The LEDD increased 5\u2009years after surgery compared to that at baseline. Eleven patients had passed away during follow\u2010up, the mean survival time was 38.3\u2009\u00b1\u200917.3\u2009months after surgery, and the mean age at the time of death was 81.2 (range 75\u201387) years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Robot\u2010assisted DBS surgery for the elderly patients with Parkinson's disease is accurate and safe. Motor symptoms and ADL significantly improve and patients can benefit from long\u2010term neuromodulation, which may decrease the risk of death.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.14899","type":"journal-article","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T00:53:08Z","timestamp":1722991988000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Safety and efficiency of deep brain stimulation in the elderly patients with Parkinson's disease"],"prefix":"10.1111","volume":"30","author":[{"given":"Weidong","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Neurosurgery General Hospital of Northern Theater Command  Shenyang China"},{"name":"China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery General Hospital of Northern Theater Command  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery General Hospital of Northern Theater Command  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery General Hospital of Northern Theater Command  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijia","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery General Hospital of Northern Theater Command  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery First Hospital of Jilin University  Changchun 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