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We therefore used a multivariate data\u2010driven method to search for dynamic functional network connectivity (dFNC) alterations in SAD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted spatial independent component analysis, and used a sliding\u2010window approach with a k\u2010means clustering algorithm, to characterize the recurring states of brain resting\u2010state networks; then state transition metrics and FNC strength in the different states were compared between SAD patients and healthy controls (HC), and the relationship to SAD clinical characteristics was explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four distinct recurring states were identified. Compared with HC, SAD patients demonstrated higher fractional windows and mean dwelling time in the highest\u2010frequency State 3, representing \u201cwidely weaker\u201d FNC, but lower in States 2 and 4, representing \u201clocally stronger\u201d and \u201cwidely stronger\u201d FNC, respectively. In State 1, representing \u201cwidely moderate\u201d FNC, SAD patients showed decreased FNC mainly between the default mode network and the attention and perceptual networks. Some aberrant dFNC signatures correlated with illness duration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These aberrant patterns of brain functional synchronization dynamics among large\u2010scale resting\u2010state networks may provide new insights into the neuro\u2010functional underpinnings of SAD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.14904","type":"journal-article","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T04:38:25Z","timestamp":1723005505000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Abnormal large\u2010scale brain functional network dynamics in social anxiety disorder"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6567-6702","authenticated-orcid":false,"given":"Xun","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Radiology and Huaxi MR Research Center (HMRRC), Functional and 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