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High\u2010resolution MRI volume\u2010based analysis and\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010FDG\u2010PET standard uptake values of hippocampal and amygdala subfields were quantified and compared with 57 matched controls. Further analyses were conducted to delineate the distinct pathological characteristics differentiating the two groups. Diagnostic and prognostic prediction performance of these biomarkers were assessed using receiver operating characteristic curves.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      LVF\u2010onset individuals demonstrated ipsilateral amygdala enlargement (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.048) and contralateral hippocampus hypermetabolism (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.042), pathological results often accompany abnormalities in the temporal lobe cortex, while HYP\u2010onset subjects had significant atrophy (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and hypometabolism (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013) in ipsilateral hippocampus and its subfields, as well as amygdala atrophy (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), pathological results are highly correlated with hippocampal sclerosis. Severe fimbria atrophy was observed in cases of HYP\u2010onset MTLE with poor prognosis (AUC\u2009=\u20090.874).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Individuals with different seizure\u2010onset patterns display specific morphological and metabolic abnormalities in the amygdala and hippocampus. Identifying these subfield abnormalities can improve diagnostic and prognostic precision, guiding surgical strategies for MTLE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.14905","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T08:46:22Z","timestamp":1725871582000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Delineating structural and metabolic abnormalities in amygdala and hippocampal subfields for different seizure\u2010onset patterns via stereotactic electroencephalography"],"prefix":"10.1111","volume":"30","author":[{"given":"Tao","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Xuanwu Hospital, Capital Medical University  Beijing China"},{"name":"China International Neuroscience Institute (CHINA\u2010INI)  Beijing 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Neuroscience Institute (CHINA\u2010INI)  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianren","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Xuanwu Hospital, Capital Medical University  Beijing China"},{"name":"China International Neuroscience Institute (CHINA\u2010INI)  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuda","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Xuanwu Hospital, Capital Medical University  Beijing China"},{"name":"China International Neuroscience Institute (CHINA\u2010INI)  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sichang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Xuanwu Hospital, Capital Medical University  Beijing China"},{"name":"China International Neuroscience Institute (CHINA\u2010INI)  Beijing 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