{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:06:32Z","timestamp":1792638392375,"version":"4.5.0"},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:00:00Z","timestamp":1723161600000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate the efficacy, safety, and tolerability of adjunctive lacosamide therapy against focal seizures in young children (1\u2009month\u2009\u2013\u20094\u2009years).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This non\u2010randomized, open\u2010label, and self\u2010controlled real\u2010world study included 105 children (1\u2009month\u20134\u2009years) with focal seizures treated with adjunctive lacosamide therapy at Children's Hospital of Chongqing Medical University.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      (1) The 50% response rates at 3, 6, 9, and 12\u2009months of follow\u2010up were 58.1%, 61.0%, 57.1%, and 56.2%, while the seizure\u2010free rates were 27.6%, 34.3%, 32.4%, and 37.1%, respectively. The 50% response rate of the first addition of lacosamide for focal seizures was much higher than the second and later added treatment at 3\u2009months (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.038). After 1\u2009year of follow\u2010up, these children showed an improvement in neurodevelopmental levels (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). (2) Lacosamide retention rate was 72.7% (64\/88) after 1\u2009year of follow\u2010up. Lack of efficacy and serious adverse events were independent risk factors for the lacosamide retention rate. (3) During adjunctive lacosamide therapy, 13 (12.4%) patients reported adverse events and five (4.7%) patients withdrew due to adverse events, including vomiting drowsiness, ataxia (0.94%), neck itching with eczema (0.94%), irritability (1.88%), and gastrointestinal discomfort (0.94%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Adjunctive lacosamide therapy was effective, safe, and well\u2010tolerated in young Chinese children with focal seizures in this study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.14917","type":"journal-article","created":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T00:13:31Z","timestamp":1723248811000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Efficacy, safety, and tolerability of adjunctive Lacosamide therapy for focal seizures in young children aged \u22651\u2009month to \u22644\u2009years: A real\u2010world study"],"prefix":"10.1111","volume":"30","author":[{"given":"Lu","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Neurology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation base of Child development and Critical Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Big Data Engineering Center Children's Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation base of Child development and Critical Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Big Data Engineering Center Children's Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Neurology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation base of Child development and Critical Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Big Data Engineering Center Children's Hospital of Chongqing Medical University Chongqing 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