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Few studies have investigated the cerebral perfusion response to fasting\u2013postprandial metabolic switching (FMS) in AD patients. We aimed to evaluate the cerebral perfusion response to FMS in AD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 30 AD patients, 32 mild cognitive impairment (MCI) patients, and 30 healthy control individuals (HCs) were included in the quantification of cerebral perfusion via cerebral blood flow (CBF). The cerebral perfusion response to FMS was defined as the difference (\u0394CBF) between fasting and postprandial CBF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with AD had a regional negative \u0394CBF in the anterior temporal lobe, part of the occipital lobe and the parietal lobe under FMS stimulation, whereas HCs had no significant \u0394CBF. The AD patients had lower \u0394CBF values in the right anterior temporal lobe than the MCI patients and HCs. \u0394CBF in the anterior temporal lobe was negatively correlated with cognitive severity and cognitive reserve factors in AD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>AD patients exhibited a poor ability to maintain cerebral perfusion homeostasis under FMS stimulation. The anterior temporal lobe is a distinct area that responds to FMS in AD patients and negatively correlates with cognitive function.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.70014","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T13:30:08Z","timestamp":1726061408000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Neuroimaging analysis reveals distinct cerebral perfusion responses to fasting\u2010postprandial metabolic switching in Alzheimer's disease patients"],"prefix":"10.1111","volume":"30","author":[{"given":"Runzhi","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"Department of Neurology, Shanxi Provincial People's Hospital The Fifth Clinical Medical College of Shanxi Medical University  Taiyuan China"},{"name":"Shanxi Key Laboratory of Brain Disease Control, 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