{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T08:23:35Z","timestamp":1768811015455,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:00:00Z","timestamp":1724976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073820"],"award-info":[{"award-number":["82073820"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Parkinson's disease (PD) is a prevalent neurodegenerative disorder characterized by dopaminergic neuron degeneration and diverse motor and nonmotor symptoms. Early diagnosis and intervention are crucial but challenging due to reliance on clinical presentation. Recent research suggests potential biomarkers for early detection, including plasma netrin\u20101 (NTN\u20101), a protein implicated in neuronal survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional study recruited 105 PD patients and 65 healthy controls, assessing plasma NTN\u20101 levels and correlating them with clinical characteristics. Statistical analyses explored associations between NTN\u20101 levels and PD symptoms, considering demographic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PD patients exhibited significantly lower plasma NTN\u20101 levels compared to controls. NTN\u20101 demonstrated moderate potential as a PD biomarker. Positive correlations were found between NTN\u20101 levels and motor, depression, and cognitive symptoms. Multiple regression analysis revealed disease duration and NTN\u20101 levels as key factors influencing symptom severity. Gender also impacted symptom scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Reduced plasma NTN\u20101 levels correlate with PD severity, suggesting its potential as a biomarker. However, further research is needed to elucidate the roles of NTN\u20101 in PD pathophysiology and validate its diagnostic and therapeutic implications. Understanding the involvement of NTN\u20101 may lead to personalized management strategies for PD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.70022","type":"journal-article","created":{"date-parts":[[2024,8,31]],"date-time":"2024-08-31T04:35:05Z","timestamp":1725078905000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association between plasma Netrin\u20101 levels and motor and nonmotor symptoms in Parkinson's disease"],"prefix":"10.1111","volume":"30","author":[{"given":"Ye","family":"Hua","sequence":"first","affiliation":[{"name":"Department of Neurology The Second Affiliated Hospital of Soochow University  Suzhou China"},{"name":"Department of Neurology Wuxi No. 2 People's Hospital, Jiangnan University Medical Center  Wuxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Neuroprotective Drug 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