{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T02:19:38Z","timestamp":1788574778279,"version":"build-2803163510"},"reference-count":61,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T00:00:00Z","timestamp":1725321600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The study aimed to evaluate the potential benefits of luteolin treatment in Huntington's disease (HD), an inherited progressive neurodegenerative disorder.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>HD N171\u201082Q transgenic and WT mice received luteolin or vehicle for treatment at 6\u2009weeks of age. The mice's body weight changes and survival rates were monitored throughout the study, and a series of motor functional tests were conducted. Serum level of the marker NfL was also determined. Immunohistochemical staining and western blotting were utilized to assess the expression of huntingtin aggregates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Luteolin treatment enhanced survival and prevented weight loss in HD mice compared to the vehicle\u2010treated HD group. Furthermore, the luteolin\u2010treated HD mice exhibited enhanced motor coordination and balance and significantly reduced motor dysfunction. Also, luteolin decreased serum NfL levels in HD mice. Notably, the accumulation of huntingtin aggregates was significantly reduced in the brain's cortex, hippocampus, and striatum of luteolin\u2010treated HD mice compared to the vehicle\u2010treated HD group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Luteolin holds promise as a therapeutic agent for improving survival outcomes, managing motor dysfunction, and reducing huntingtin aggregates in HD. The findings are of significance as currently, there are no approved therapeutic interventions that reverse HD pathology or slow down its progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.70025","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:35:45Z","timestamp":1725410145000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Luteolin as potential treatment for Huntington's disease: Insights from a transgenic mouse model"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4435-3791","authenticated-orcid":false,"given":"Abuelnor","family":"Mohammed","sequence":"first","affiliation":[{"name":"Department of Basic Medical Sciences College of Medicine\u2010Dar Al Uloom University  Riyadh Saudi Arabia"},{"name":"Department of Histology and Embryology, School of Basic Medical Sciences, Tongji Medical College Huazhong 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