{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T23:01:35Z","timestamp":1771974095425,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:00:00Z","timestamp":1725408000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071263"],"award-info":[{"award-number":["82071263"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate post\u2010operative seizure outcomes, and predictors of surgical outcomes of the malformation of cortical development (MCD) in children with drug\u2010resistant epilepsy (DRE) and age\u2010specific characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed clinical data from 428 children with MCD\u2010related DRE who underwent curative surgical treatment. Statistical analyses were conducted to identify correlative characteristics, prognostic predictors, and differences among various age groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After more than 3\u2009years of follow\u2010up, 81.3% of patients achieved Engel I outcomes. Prognosis was correlated with factors such as age at surgery, MRI findings, invasive EEG, pathology, acute postoperative seizures (APOS), and the number of preoperative and postoperative anti\u2010seizure medications (AEDs). Age at surgery and the number of preoperative AEDs (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) were significant predictors of seizure recurrence. Distinct clinical characteristics were observed among different age groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Surgery is effective in terminating MCD\u2010related DRE. Younger age at surgery and fewer preoperative AEDs are associated with better prognoses. Clinical characteristics vary significantly with age.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.70031","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T04:26:23Z","timestamp":1725510383000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical characteristics and post\u2010operative outcomes in children with malformation of cortical development related drug\u2010resistant epilepsy: 428 cases in one pediatric epilepsy center"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5164-4792","authenticated-orcid":false,"given":"Hao","family":"Yu","sequence":"first","affiliation":[{"name":"Pediatric Epilepsy Center Peking University First Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Sun","sequence":"additional","affiliation":[{"name":"Pediatric Epilepsy Center Peking University First 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