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After 6\u2009months of medication treatment, 40 subjects underwent a follow\u2010up scan in euthymic state. Metabolite levels, including N\u2010acetyl aspartate (NAA), glutamate (Glu), and Glutamine (Gln), were measured in the mPFC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients experiencing depressive and manic episodes exhibited a notable reduction in NAA\/Cr\u2009+\u2009PCr ratios at baseline compared to healthy controls (<jats:italic>p<\/jats:italic>\u2009=\u20090.004; <jats:italic>p<\/jats:italic>\u2009=\u20090.006) in baseline, compared with HCs. Over the 6\u2010month follow\u2010up period, the manic group displayed a significant decrease in Gln\/Cr\u2009+\u2009PCr compared to the initial acute phase (<jats:italic>p<\/jats:italic>\u2009=\u20090.03). No significant alterations were found in depressed group between baseline and follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study suggests that NAA\/Cr\u2009+\u2009PCr ratios and Gln\/Cr\u2009+\u2009PCr ratios in the mPFC may be associated with manic and depressive episodes, implicating that Gln and NAA might be useful biomarkers for distinguishing mood phases in BD and elucidating its mechanisms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.70048","type":"journal-article","created":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T03:29:31Z","timestamp":1726802971000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Changes in the medial prefrontal cortex metabolites after 6\u2009months of medication therapy for patients with bipolar disorder: A <scp><sup>1<\/sup>H<\/scp>\u2010<scp>MRS<\/scp> study"],"prefix":"10.1111","volume":"30","author":[{"given":"Haijin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Psychiatry The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1842-0364","authenticated-orcid":false,"given":"Ju","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Geriatric Psychiatry, Suzhou Mental Health Center, Suzhou Guangji Hospital The Affiliated Guangji Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Geriatric Psychiatry, Suzhou Mental Health Center, Suzhou Guangji Hospital The Affiliated Guangji Hospital of Soochow University  Suzhou 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