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This review aims to explore the intricate relationship between aging, mHTT toxicity, and cellular senescence in HD. Scientific data on the interplay between aging, mHTT, and cellular senescence in HD were collected from several academic databases, including PubMed, Google Scholar, Google, and ScienceDirect. The search terms employed were \u201cAGING,\u201d \u201cHUNTINGTON'S DISEASE,\u201d \u201cMUTANT HUNTINGTIN,\u201d and \u201cCELLULAR SENESCENCE.\u201d Additionally, to gather information on the molecular mechanisms and potential therapeutic targets, the search was extended to include relevant terms such as \u201cDNA DAMAGE,\u201d \u201cOXIDATIVE STRESS,\u201d and \u201cAUTOPHAGY.\u201d According to research, aging leads to worsening HD pathophysiology through some processes. As a result of the mHTT accumulation, cellular senescence is promoted, which causes DNA damage, oxidative stress, decreased autophagy, and increased inflammatory responses. Pro\u2010inflammatory cytokines and other substances are released by senescent cells, which may worsen the neuronal damage and the course of the disease. It has been shown that treatments directed at these pathways reduce some of the HD symptoms and enhance longevity in experimental animals, pointing to a new possibility of treating the condition. Through their amplification of the harmful effects of mHTT, aging and cellular senescence play crucial roles in the development of HD. Comprehending these interplays creates novel opportunities for therapeutic measures targeted at alleviating cellular aging and enhancing HD patients\u2019 quality of life.<\/jats:p>","DOI":"10.1111\/cns.70053","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T02:23:53Z","timestamp":1729477433000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Therapeutic approaches targeting aging and cellular senescence in Huntington's disease"],"prefix":"10.1111","volume":"30","author":[{"given":"Asif Ahmad","family":"Bhat","sequence":"first","affiliation":[{"name":"Uttaranchal Institute of Pharmaceutical Sciences Uttaranchal University  Dehradun India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehssan","family":"Moglad","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, College of Pharmacy Prince Sattam Bin Abdulaziz University  Al Kharj Saudi 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