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We conducted an exposome\u2010wide association study using the least absolute shrinkage and selection operator (LASSO) technique. Restricted cubic splines (RCS) were further employed to estimate potential nonlinear correlations. Weighted standardized scores for neuroimaging markers were computed based on the estimates for individual factors. Finally, stratum\u2010specific analyses were performed to examine differences in factors affecting brain health at different ages.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The identified factors related to neuroimaging markers of brain health fell into six domains, including systematic diseases, lifestyle factors, personality traits, social support, anthropometric indicators, and biochemical markers. The explained variance percentage of neuroimaging markers by weighted standardized scores ranged from 0.5% to 7%. Notably, associations between systematic diseases and neuroimaging markers were stronger in older individuals than in younger ones.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study identified a series of factors related to neuroimaging markers of brain health. Targeting the identified factors might help in formulating effective strategies for maintaining brain health.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.70057","type":"journal-article","created":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T11:29:39Z","timestamp":1728991779000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Identifying modifiable factors associated with neuroimaging markers of brain health"],"prefix":"10.1111","volume":"30","author":[{"given":"Liang\u2010Yu","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Neurology Qingdao Municipal Hospital, Qingdao University  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Neurology Qingdao Municipal Hospital, Qingdao University  Qingdao 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