{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T15:49:52Z","timestamp":1783698592306,"version":"3.55.0"},"reference-count":57,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T00:00:00Z","timestamp":1728345600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The pathophysiology behind memory impairment in Parkinson's Disease Mild Cognitive Impairment (PD\u2010MCI) is unclear. This study aims to investigate the hippocampal and cortical atrophy patterns in PD\u2010MCI patients with different types of memory impairments, categorized as Retrieval Failure (RF) and Encoding Failure (EF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included 16 healthy controls (HC) and 34 PD\u2010MCI patients, divided into RF (<jats:italic>N<\/jats:italic>\u2009=\u200918) and EF (<jats:italic>N<\/jats:italic>\u2009=\u200916) groups based on their Verbal Memory Processes Test (VMPT) scores, including spontaneous recall, recognition, and Index of Sensitivity to Cueing (ISC). Hippocampal subfields and cortical thicknesses were measured using the FreeSurfer software for automatic segmentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to the HC group, the EF group exhibited significant atrophy in the left lateral occipital region and the right caudal middle frontal, superior temporal, and inferior temporal regions (p\u27e80.05). The RF group displayed significant atrophy in the left lateral occipital, middle temporal, and precentral regions, as well as the right pars orbitalis and superior frontal regions (p\u27e80.05). Hippocampal subfield analysis revealed distinct volume differences between HC\u2010EF and RF\u2010EF groups, with significant reductions in the CA1, CA3, and CA4 subregions in the EF group, but no differences between HC and RF groups (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Gray matter atrophy patterns differ in PD\u2010MCI patients with encoding and retrieval memory impairments. The significant hippocampal atrophy in the EF group, particularly in the CA subregions, highlights its potential role in disease progression and memory decline. Additionally, the convergence of atrophy in the lateral occipital cortex across both RF and EF groups suggests the involvement of the Parietal Memory Network (PMN) in PD\u2010related memory impairment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.70062","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T04:39:30Z","timestamp":1728448770000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Parietal memory network and memory encoding versus retrieval impairments in PD\u2010MCI patients: A hippocampal volume and cortical thickness study"],"prefix":"10.1111","volume":"30","author":[{"given":"Serhat","family":"Sahin","sequence":"first","affiliation":[{"name":"Functional Imaging and Cognitive\u2010Affective Neuroscience Lab (fINCAN) Health Sciences and Technology Research Institute (SABITA), Istanbul Medipol University  Istanbul 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