{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:40:00Z","timestamp":1787240400214,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273984"],"award-info":[{"award-number":["82273984"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFC1708504"],"award-info":[{"award-number":["2019YFC1708504"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Dopamine transporter (DAT) can regulate DA homeostasis and has been implicated in many nervous system diseases. Whether DAT is involved in the protection against ischemic stroke is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In vivo microdialysis measurements of DA were recorded in the ischemic penumbral area of mice with middle cerebral artery occlusion (MCAO). DAT coding gene,\n                      <jats:italic>Slc6a3<\/jats:italic>\n                      mutation, and DAT overexpression animals were performed MCAO. Madopar (compound formulation of levodopa) and nomifensine (DA reuptake inhibitor) were administered in MCAO animals. Brain slices were prepared in\n                      <jats:italic>Slc6a3<\/jats:italic>\n                      mutation or wild\u2010type (WT) animals with MCAO to record miniature excitatory postsynaptic currents (mEPSCs) and miniature inhibitory postsynaptic currents (mIPSCs). The effects of DA and its dopamine\u20101 receptor (D\n                      <jats:sub>1<\/jats:sub>\n                      R) antagonists (SCH\u201023390) on mEPSCs, mIPSCs, and neurons protection were recorded.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      MCAO caused a prominent increase in DA.\n                      <jats:italic>Slc6a3<\/jats:italic>\n                      mutation significantly attenuated the ischemic injury, whereas DAT overexpression aggravated this injury. Both nomifensine and madopar protected against brain injury.\n                      <jats:italic>Slc6a<\/jats:italic>\n                      3 mutation and DA restored the disturbance of mEPSCs and mIPSC, and protected against neuron death, which was abolished by SCH\u201023390.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      DAT inhibition might be explored as a strategy for ischemic stroke prevention. DA and D\n                      <jats:sub>1<\/jats:sub>\n                      R involve in the restoration of synaptic dysfunction and neuron protection.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.70092","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T23:54:33Z","timestamp":1730159673000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Dopamine Transporter Is a New Target for Ischemic Stroke"],"prefix":"10.1111","volume":"30","author":[{"given":"Yan\u2010Qiong","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Pharmacy Research, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruo\u2010Xi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Research, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing\u2010Yuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Research, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Ting","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Research, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Chen","sequence":"additional","affiliation":[{"name":"MOE Frontier Center for Brain Science, Institutes of Brain Science, State Key Laboratory of Medical Neurobiology Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3256-644X","authenticated-orcid":false,"given":"Ai\u2010Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Research, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1150355"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0223-21.2021"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-021-01341-5"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-018-1957-2"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2020.06.137"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.119.256818"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-018-0114-5"},{"key":"e_1_2_11_9_1","article-title":"The 3'UTR VNTR SLC6A3 Genetic Variant and Major Depressive Disorder: A Systematic Review","volume":"11","author":"Gontijo B. R.","year":"2023","journal-title":"Biomedicine"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.02.026"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043229"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(87)90463-0"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2013.69"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.11.068"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/2243717"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2007.02.024"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.30.2.433"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000124127.57946.a1"},{"key":"e_1_2_11_19_1","first-page":"531","article-title":"Dopamine in the Hippocampus Is Cleared by the Norepinephrine Transporter","volume":"15","author":"Borgkvist A.","year":"2012","journal-title":"International Journal of Neuropsychopharmacology"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.21554"},{"key":"e_1_2_11_21_1","first-page":"1957","article-title":"Madopar: More Than 20\u2009Years","volume":"25","author":"Leiva C.","year":"1997","journal-title":"Revista de Neurologia"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-015-0545-1"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00119"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.11.011"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.506824"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12131737"},{"issue":"106","key":"e_1_2_11_27_1","first-page":"29","article-title":"Dopamine Transporter Scan (DAT) in Parkinsonism\u2014A Short Review for Non\u2010Neurologists","volume":"2023","author":"Gopalakrishnan B.","year":"2013","journal-title":"Rhode Island Medical Journal"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.116.232371"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1988.tb01111.x"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.638767"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2002.8033"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(98)00333-1"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(00)00067-8"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-014-9560-1"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23690"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.10.035"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-020-00857-y"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.01.092"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.866738"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.00051"}],"container-title":["CNS Neuroscience &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cns.70092","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T08:38:22Z","timestamp":1730191102000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cns.70092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":39,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1111\/cns.70092"],"URL":"https:\/\/doi.org\/10.1111\/cns.70092","archive":["Portico"],"relation":{},"ISSN":["1755-5930","1755-5949"],"issn-type":[{"value":"1755-5930","type":"print"},{"value":"1755-5949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"2024-07-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70092"}}