{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T12:17:09Z","timestamp":1772713029305,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82203170"],"award-info":[{"award-number":["82203170"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7202021"],"award-info":[{"award-number":["7202021"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Supplementary motor area (SMA) syndrome commonly occurs after glioma resection and requires weeks to months of recovery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010four glioma patients with SMA syndrome were reviewed and assigned to recovered and non\u2010recovered groups based on whether their motor function recovered on postoperative day 7. To validate the association between variations in nodal properties and recovery time, neuro\u2010navigated repetitive transcranial magnetic stimulation (nrTMS) was applied to stimulate potential nodes. Nine other patients (five nrTMS therapy and four sham\u2010nrTMS treatments) with SMA syndrome with unrecovered motor functions on postoperation day 7 were prospectively enrolled.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The potential nodes of the sensorimotor network related to recovery time were investigated using preoperative and postoperative resting\u2010state functional magnetic resonance imaging, graph theoretical analysis, and dynamic functional connectome analysis. Nodal efficiency of the lesional\u2010hemispheric upper limb region of BA 4 (A4ul_L) increased in the recovered group (preoperative, 0.472\u2009\u00b1\u20090.027; postoperative, 0.535\u2009\u00b1\u20090.020; <jats:italic>p<\/jats:italic>\u2009=\u20090.0006). The patients in the nrTMS therapy group quickly recovered (12.0\u2009\u00b1\u20091.6\u2009days) compared to the sham\u2010nrTMS group (29.5\u2009\u00b1\u20093.8\u2009days, <jats:italic>p<\/jats:italic>\u2009=\u20090.0024). Variations in A4ul_L nodal efficiency was negatively correlated with recovery time (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.841; <jats:italic>p<\/jats:italic>\u2009=\u20090.0046).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A4ul_L demonstrates enhanced postoperative nodal efficiency and shows therapeutic potential in SMA syndrome recovery, suggesting its viability as a therapeutic target.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.70112","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T12:24:41Z","timestamp":1731500681000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Postoperative Nodal Efficiency of the Lesional\u2010Hemispheric Hand Motor Area Increasing Potentially Facilitated Motor Recovery for SMA Syndrome"],"prefix":"10.1111","volume":"30","author":[{"given":"Shimeng","family":"Weng","sequence":"first","affiliation":[{"name":"Beijing Neurosurgical Institute Capital Medical University  Beijing China"},{"name":"Department of Neurosurgery Beijing Tiantan Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoting","family":"Meng","sequence":"additional","affiliation":[{"name":"Universal Medical Imaging Diagnostic Center  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianwang","family":"Li","sequence":"additional","affiliation":[{"name":"Tianjin Huanhu Hospital  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinshi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Health, School of Public Health China Medical University  Shenyang 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