{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:35:54Z","timestamp":1791920154242,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:00:00Z","timestamp":1730764800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The oxidative stress and neuroinflammation are important factors in acute ischemic stroke (AIS). Our former study showed the 1,2,4\u2010 triazole derivative (SYS18) had obviously neuroprotection by anti\u2010 oxidative stress on rat middle cerebral artery occlusion (MCAO) model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>In this study, we continue to investigate its neuroprotection by anti\u2010inflammatory effects and protecting BBB integrity in AIS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>First, its effect on acute inflammation was evaluated by the mice model of increased peritoneal capillary permeability. Then, the MCAO cerebral edema models were built to evaluate its neuroprotection by reducing the neurological score, cerebral edema, improving the biochemical indicators, and pathological damage of brain tissue. At the same time, its protection on blood\u2013brain barrier (BBB) integrity was proved by decreasing the BBB permeability and inhibiting glycocalyx degradation and regulating the BBB tight junction proteins expression of matrix metalloproteinase\u2010 9 (MMP\u2010 9) and claudin\u2010 5 in brain tissue. Meanwhile, pharmacokinetic experiments showed that the compound had good BBB penetration. It has some advantages in the intensity of efficacy compared with the marketed drug edaravone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Based on these findings, SYS18 has a strong potential to become a neuroprotectant in the future.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.70113","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T03:39:12Z","timestamp":1730864352000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The Neuroprotection of 1,2,4\u2010Triazole Derivative by Inhibiting Inflammation and Protecting BBB Integrity in Acute Ischemic Stroke"],"prefix":"10.1111","volume":"30","author":[{"given":"Xuan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Medicinal Chemistry, School of Pharmaceutical Science Sun Yat\u2010Sen University  Guangzhou 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