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While chronic kidney disease (CKD) has long been established as a significant risk factor for cerebrovascular disease, stroke can induce renal dysfunction, manifesting as acute kidney injury (AKI) or CKD. Mounting clinical and basic research evidence supports the existence of a bidirectional brain\u2010kidney crosstalk following stroke, implicating specific mechanisms and pathways in stroke\u2010related renal dysfunction. This review analyzes pertinent experimental studies, elucidating the underlying mechanisms of this cerebro\u2010renal interaction following stroke. Additionally, we summarize the current landscape of clinical research investigating brain\u2010kidney interplay and discuss potential challenges in the future. By enhancing our understanding of the scientific underpinnings of brain\u2010kidney crosstalk, this review paves the way for improved treatment strategies and outcomes for stroke patients. Recognizing the intricate interplay between the brain and kidneys after stroke holds profound clinical implications.<\/jats:p>","DOI":"10.1111\/cns.70114","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T06:58:38Z","timestamp":1731481118000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Stroke\u2010Induced Renal Dysfunction: Underlying Mechanisms and Challenges of the Brain\u2013Kidney Axis"],"prefix":"10.1111","volume":"30","author":[{"given":"Xi","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Zhujiang Hospital of Southern Medical University  Guangzhou China"},{"name":"College of Anesthesiology Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Xiao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Zhujiang Hospital of 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