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While the precise etiology of MS remains elusive, compelling research underscores the pivotal role of the immune response in disease progression. Notably, recent investigations highlight the significant involvement of NLRP3 inflammasomes in various autoimmune diseases, prompting an in\u2010depth exploration of their impact on MS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The review focuses on elucidating the activation mechanism of NLRP3 inflammasomes within microglia\/macrophages (MG\/M\u0424), examining how this activation promotes an inflammatory response that exacerbates neuronal damage in MS. A comprehensive analysis of existing literature and research findings forms the basis for understanding the intricate interplay between NLRP3 inflammasomes and MS pathogenesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Synthesizing current research, the review provides insight into the pivotal role played by NLR inflammasomes, specifically NLRP3, in MS. Emphasis is placed on the inflammatory response orchestrated by activated MG\/M\u0424, elucidating the cascade that perpetuates neuronal damage in the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This review concludes by consolidating key findings and offering a nuanced perspective on the role of NLRP3 inflammasomes in MS pathogenesis. The detailed exploration of the activation process within MG\/M\u0424 provides a foundation for understanding the disease's underlying mechanisms. Furthermore, the review sets the stage for potential therapeutic strategies targeting NLRP3 inflammasomes in the pursuit of MS treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.70135","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T06:30:40Z","timestamp":1734503440000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Microglial Mayhem <scp>NLRP3<\/scp> Inflammasome's Role in Multiple Sclerosis Pathology"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9067-1884","authenticated-orcid":false,"given":"Hua","family":"Fan","sequence":"first","affiliation":[{"name":"Office of Research &amp; Innovation The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology  Luoyang 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