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With bio\u2010mimic mechanic cues, the dynamic hydrogels with dynamic stiffness changes or reversible crosslinking have been suggested to construct the in\u00a0vitro disease models or novel therapeutic agents for TBI. However, there is a lack of clarification on the dynamic hydrogels currently reported and their biomedical applications on TBI. Our review starts with introducing the native mechanical characters and changes in TBI and then summarizes the common chemical strategies of the dynamic hydrogels with dynamically tunable stiffness and reversible networks for in\u00a0vitro modeling and therapy. 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