{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T20:24:37Z","timestamp":1783110277124,"version":"3.54.6"},"reference-count":57,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T00:00:00Z","timestamp":1735084800000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81601478"],"award-info":[{"award-number":["81601478"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071910"],"award-info":[{"award-number":["82071910"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of this study was to investigate the whole\u2010brain asymmetry changes in spinocerebellar ataxia type 3 (SCA3) and their association with movement disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Voxel\u2010based morphometry (VBM) was used to assess asymmetry in gray matter (GM) volume in 83 genetically confirmed SCA3 patients and 83 sex\u2010 and age\u2010matched healthy controls (HCs). The asymmetry index (AI) was analyzed for partial correlation with disease severity, as measured by the Scale for Assessment and Rating of Ataxia (SARA) and International Cooperative Ataxia Rating Scale (ICARS). Age, sex, and total intracranial volume (TIV) were included as covariates in the analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Asymmetry in GM analysis with SCA3 patients showed decreased leftward asymmetry in cerebellar lobules VIII and IX, the visual cortex, and the putamen, as well as decreased rightward asymmetry in the ventral lateral thalamus, as analyzed by VBM. The AI in the cerebellum, the visual cortex, and the putamen was positively correlated with SARA and ICARS scores, whereas the AI in the thalamus was negatively correlated with these scales.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SCA3 patients exhibit distinct patterns of asymmetrical changes in GM volume, which correlates with motor dysfunction. These changes in asymmetry may serve as potential biomarkers for early intervention in SCA3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.chictr.org.cn\/\">Chinese Clinical Trial Registry<\/jats:ext-link> (ChiCTR): 1800019901, 2000039434<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.70171","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T04:35:19Z","timestamp":1735187719000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Gray Matter Asymmetry Alterations in Patients With Spinocerebellar Ataxia Type 3: A Voxel\u2010Based Morphometric Comparison Study"],"prefix":"10.1111","volume":"30","author":[{"given":"Linfeng","family":"Shi","sequence":"first","affiliation":[{"name":"7T Magnetic Resonance Imaging Translational Medical Center, Department of Radiology, 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