{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:44:42Z","timestamp":1790912682593,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:00:00Z","timestamp":1735171200000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2023MH076"],"award-info":[{"award-number":["ZR2023MH076"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to explore the role and underlying mechanisms of brain\u2010derived exosomes in traumatic brain injury\u2010induced acute lung injury (TBI\u2010induced ALI), with a particular focus on the potential regulation of ferroptosis through miRNAs and Scd1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      To elucidate TBI\u2010induced ALI, we used a TBI mouse model. Exosomes were isolated from the brains of these mice and characterized using TEM and NTA. LC\u2013MS analysis revealed an increase in the level of ferroptosis in the lung tissues of mice with TBI. Subsequent miRNA and mRNA sequencing revealed the upregulation of miR\u20109\u20105p and the downregulation of Scd1 in the pulmonary tissues of these mice. Ferroptosis was assessed by quantifying the levels of ROS, MDA, and Fe\n                      <jats:sup>2+<\/jats:sup>\n                      and the expression of proteins associated with ferroptosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>TBI led to the release of exosomes enriched with miR\u20109\u20105p, which targeted Scd1 in lung tissue, thereby promoting ferroptosis. Treatment with antagomir 9\u20105p reduced the level of ALI in TBI mice, indicating that exosomal miR\u20109\u20105p plays a significant role in TBI\u2010induced ALI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study revealed that brain\u2010derived exosomal miR\u20109\u20105p mediates ferroptosis in TBI\u2010induced ALI by targeting Scd1. These findings may provide new insights into the complex interplay between TBI and ALI and highlight the potential of miR\u20109\u20105p as a target for the development of novel therapeutic strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.70189","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T05:37:52Z","timestamp":1735191472000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Brain\u2010Derived Exosomal miR\u20109\u20105p Induces Ferroptosis in Traumatic Brain Injury\u2010Induced Acute Lung Injury by Targeting Scd1"],"prefix":"10.1111","volume":"30","author":[{"given":"Yi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong China"},{"name":"Department of Anesthesiology, Shandong Provincial Hospital Shandong University  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