{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:25:06Z","timestamp":1787498706062,"version":"build-2736575974"},"reference-count":68,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2024QH384"],"award-info":[{"award-number":["ZR2024QH384"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lysosome is a highly heterogeneous membranous organelle in eukaryotic cells, which regulates many physiological processes in the cell. Studies have found that lysosomal dysfunction disrupts cellular homeostasis and is associated with Parkinson's disease (PD). Transmembrane protein 175 (TMEM175) is a lysosomal cation channel whose activity is essential for lysosomal homeostasis. At present, it has been confirmed that TMEM175 is related to the pathogenesis of PD, but the relationship between the two remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>A thorough comprehension of the structure and function of TMEM175 would greatly contribute to elucidating the achievement of this objective. In this paper, the structure, composition, and function of TMEM175 and its relationship with PD will be reviewed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.70195","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T02:18:40Z","timestamp":1737425920000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["What We Know About\n                    <scp>TMEM175<\/scp>\n                    in Parkinson's Disease"],"prefix":"10.1111","volume":"31","author":[{"given":"Jing","family":"Wang","sequence":"first","affiliation":[{"name":"Medical Record Information Section Yantai Yuhuangding Hospital  Yantai Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuechun","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurology Jinan Central Hospital Affiliated to Shandong First Medical University  Jinan Shandong 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