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However, as of yet, it remains unclear whether this pattern is of genetic predisposition or related to the illness itself.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematical meta\u2010analysis was performed to identify resting\u2010state functional differences in probands and their high\u2010risk first\u2010degree relatives of schizophrenia (FDRs\u2010SCZ) using Seed\u2010based d Mapping software. Subsequently, spatial associations between postmortem gene expression and neurotransmitters distribution data and neural activity alterations were conducted to uncover neural mechanisms underlaying FDRs\u2010SCZ and SCZ from a multidimensional perspective.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 13 studies comprising 503 FDRs\u2010SCZ and 605 healthy controls (HCs) and 129 studies comprising 6506 patients with SCZ and 6982 HCs were included. Compared to HCs, FDRs\u2010SCZ displayed increased spontaneous functional activity in the bilateral anterior cingulate cortex\/medial prefrontal cortex (ACC\/mPFC); patients with SCZ showed decreased spontaneous functional activity in the bilateral ACC\/mPFC, bilateral postcentral gyrus, and right middle temporal gyrus as well as increased spontaneous functional activity in the bilateral striatum. The altered functional activity in FDRs\u2010SCZ and SCZ shared similar spatial associations with genes enriched in potassium ion transmembrane transport, channel activity, and complex. The FDRs\u2010SCZ and SCZ\u2010related brain functional patterns were additionally associated with dopaminergic, serotonergic, and cholinergic neurotransmitter distribution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SCZ\u2010related resting\u2010state functional, neuroimaging transcriptomes, and neurotransmitters abnormalities may exist in high\u2010risk unaffected FDRs\u2010SCZ, rather than just in overt SCZ. The study extended the evidence that altered brain function, along with their spatial correlations to genetics and neurotransmitter systems, may associate with genetic vulnerability for SCZ.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.70218","type":"journal-article","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T21:59:47Z","timestamp":1739224787000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Neural Activity Alterations and Their Association With Neurotransmitter and Genetic Profiles in Schizophrenia: Evidence From Clinical Patients and Unaffected Relatives"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6772-1131","authenticated-orcid":false,"given":"Zixuan","family":"Guo","sequence":"first","affiliation":[{"name":"Medical Imaging Center First Affiliated Hospital of Jinan University  Guangzhou China"},{"name":"Institute of Molecular and 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