{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:06:13Z","timestamp":1791461173709,"version":"4.3.4"},"reference-count":86,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T00:00:00Z","timestamp":1739750400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004697","name":"Hamadan University of Medical Sciences","doi-asserted-by":"publisher","award":["IR.UMSHA.REC.1400.459"],"award-info":[{"award-number":["IR.UMSHA.REC.1400.459"]}],"id":[{"id":"10.13039\/501100004697","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Physical exercise has been shown to protect against cognitive decline in Alzheimer's disease (AD), likely through the upregulation of brain\u2010derived neurotrophic factor (BDNF). Recent studies have reported that exercise activates the FNDC5\/irisin pathway in the hippocampus of mice, triggering a neuroprotective gene program that includes BDNF. This study aimed to investigate the effects of 8\u2009weeks of pretreatment with coenzyme Q10 (CoQ10) and high\u2010intensity interval training (HIIT), both individually and in combination, on FNDC5, irisin, BDNF, and amyloid\u2010beta (A\u03b2) plaque formation in the hippocampus of A\u03b2\u2010related AD rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, 72 male Wistar rats were randomly assigned to one of the following groups: control, sham, HIIT (low intensity: 3\u2009min running at 50%\u201360% VO2max; high intensity: 4\u2009min running at 85%\u201390% VO2max), Q10 (50\u2009mg\/kg, orally administered), Q10\u2009+\u2009HIIT, AD, AD + HIIT, AD + Q10, and AD + Q10\u2009+\u2009HIIT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A\u03b2 injection resulted in a trend toward decreased levels of FNDC5, irisin, and BDNF, alongside increased A\u03b2 plaque formation in the hippocampus of A\u03b2\u2010induced AD rats. However, pretreatment with CoQ10, HIIT, or their combination significantly restored hippocampal levels of FNDC5, irisin, and BDNF, while also inhibiting A\u03b2 plaque accumulation in these rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Pretreatment with CoQ10 and HIIT improved the A\u03b2\u2010induced reduction in BDNF levels probably through the FNDC5\/irisin pathway and preventing A\u03b2 plaque formation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.70221","type":"journal-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T04:44:41Z","timestamp":1739767481000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effects of Pretreatment With Coenzyme\n                    <scp>Q10<\/scp>\n                    (\n                    <scp>CoQ10<\/scp>\n                    ) and High\u2010Intensity Interval Training (\n                    <scp>HIIT<\/scp>\n                    ) on\n                    <scp>FNDC5<\/scp>\n                    , Irisin, and\n                    <scp>BDNF<\/scp>\n                    Levels, and Amyloid\u2010Beta (A\u03b2) Plaque Formation in the Hippocampus of A\u03b2\u2010Induced Alzheimer's Disease Rats"],"prefix":"10.1111","volume":"31","author":[{"given":"Samira","family":"Puoyan\u2010Majd","sequence":"first","affiliation":[{"name":"Bio\u2010Sciences Department, Physical Education and Sport Sciences Faculty Razi University  Kermanshah Iran"},{"name":"Neurophysiology Research Center Hamadan University of Medical Sciences  Hamadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdolhossein","family":"Parnow","sequence":"additional","affiliation":[{"name":"Bio\u2010Sciences Department, Physical Education and Sport Sciences Faculty Razi University  Kermanshah Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masome","family":"Rashno","sequence":"additional","affiliation":[{"name":"Asadabad School of Medical Sciences  Asadabad Iran"},{"name":"Student Research Committee, Asadabad School of Medical Sciences  Asadabad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashid","family":"Heidarimoghadam","sequence":"additional","affiliation":[{"name":"Department of Ergonomics School of Health, Hamadan University of Medical Sciences  Hamadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3865-9583","authenticated-orcid":false,"given":"Alireza","family":"komaki","sequence":"additional","affiliation":[{"name":"Neurophysiology Research Center Hamadan University of Medical Sciences  Hamadan Iran"},{"name":"Department of Neuroscience School of Science and Advanced Technologies in Medicine, Hamadan University of Medical Sciences  Hamadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv407"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-023-00473-w"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22062897"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2022.12.007"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-021-02514-7"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00171"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-005-0397-y"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-190049"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2009-1004"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2015.0825"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.09.008"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3233\/BPL-150019"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1515\/bmc-2016-0012"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10777"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9102182"},{"key":"e_1_2_11_17_1","article-title":"The Relationship of Irisin Hormone Released During Physical Exercise and Alzheimer's Disease: A Literature Review","volume":"102","author":"Gon\u00e7alves1 G. 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