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This study aimed to uncover abnormal FC patterns of FPN and LN underlying BD and their evolution following treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Imaging data at rest state and clinical variables were acquired from 82 patients with BD (with 43 finishing the follow\u2010up) and 88 healthy controls (HCs). Seed\u2010based FC analysis was performed, and correlations between FCs\u00a0and clinical variables were investigated with whole\u2010brain multiple regression analyses. Furthermore, a neuroimaging\u2013transcription spatial association analysis was conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At baseline, BD patients presented elevated FPN\u2010LN and FPN\u2013prefrontal gyrus FCs, and hyperconnectivity between the LN and bilateral thalamus, right angular gyrus (AG), and right cerebellum. Following 3\u2009months of treatment intervention, there were decreased FCs between the FPN and left superior temporal gyrus (STG), left superior frontal gyrus (SFG), left insula, and bilateral middle temporal gyrus (MTG) (part of LN). Neuroimaging transcription analysis discovered genes correlated with FC alterations in BD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Aberrant FC patterns of FPN and LN might be involved in the neural pathogenetic and therapeutic mechanisms of BD. We also provided potential genetic pathways underlying these functional impairments in BD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.70236","type":"journal-article","created":{"date-parts":[[2025,2,15]],"date-time":"2025-02-15T03:09:21Z","timestamp":1739588961000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Fronto\u2010Parietal and Language Network Connectivity and Its Association With Gene Expression Profiles in Bipolar Disorder Before and After Treatment"],"prefix":"10.1111","volume":"31","author":[{"given":"Leyi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders The Second Xiangya Hospital of Central South University  Changsha Hunan 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