{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:13:45Z","timestamp":1790108025003,"version":"4.0.1"},"reference-count":59,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,15]],"date-time":"2025-02-15T00:00:00Z","timestamp":1739577600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ischemic stroke is well\u2010known for its high mortality and morbidity, but its treatment remains to be explored due to the current limitations. For example, severe neuroinflammation occurs after ischemic stroke; however, effective neuroinflammatory inhibitors are still lacking. Thus, the development of new therapeutic targets of inhibiting neuroinflammation is urgent. CD24 is a small heavy glycosylated protein, which plays a critical role in neural development and acts as an inflammatory suppressor in tumors and autoimmune diseases. But the role of CD24 in ischemic stroke remains unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      The role of CD24 in ischemic stroke should be explored. Additionally, the potential relationship between the H\n                      <jats:sub>2<\/jats:sub>\n                      S donor, S\u2010propargyl\u2010cysteine (SPRC) and CD24 in ischemic stroke should be revealed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Mechanism studies have been performed both in\u00a0vitro and in\u00a0vivo to verify the CD24\u2010mediated inflammation and migration. SPRC has been applied to treat ischemic stroke, and its potential association with CD24 has been studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The overexpression of CD24 can inhibit the nuclear factor kappa B (NF\u2010\u03baB) inflammatory signaling pathway and promote the migration ability of M2 microglia cells via Src\/Fak\/Pyk2 signaling pathway in an inflammatory model of BV2 cells. SPRC can upregulate the level of endogenous H\n                      <jats:sub>2<\/jats:sub>\n                      S via cystathionase\u2010\u03b2\u2010synthase (CBS) and it indirectly plays a role in upregulating CD24.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CD24 could be a potential target of inhibiting neuroinflammation. SPRC reduces inflammation in ischemic stroke by regulating the CD24\/I\u03ba\u2010B\u03b1\/NF\u2010\u03baB inflammatory signaling pathway and improves the migration ability of M2 microglia via CD24\/Src\/Fak\/Pyk2 signaling pathway, which further alleviates the inflammatory response at the lesion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.70243","type":"journal-article","created":{"date-parts":[[2025,2,15]],"date-time":"2025-02-15T03:16:51Z","timestamp":1739589411000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<scp>\n                      H\n                      <sub>2<\/sub>\n                      S\n                    <\/scp>\n                    Donor\n                    <scp>SPRC<\/scp>\n                    Ameliorates Ischemic Stroke by Upregulating\n                    <scp>CD24<\/scp>"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1231-2672","authenticated-orcid":false,"given":"Chenye","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pharmacology, the Key Laboratory of Smart Drug Delivery (Ministry of Education), School of Pharmacy Minhang Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, the Key Laboratory of Smart Drug Delivery (Ministry of Education), School of Pharmacy Minhang Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qixiu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, the Key Laboratory of Smart Drug Delivery (Ministry of Education), School of Pharmacy Minhang Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Xi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, the Key Laboratory of Smart Drug Delivery (Ministry of Education), School of Pharmacy Minhang Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiejia","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Laboratory of Drug Discovery from Natural Resources and Industrializtion Macau University of Science and Technology  Macau China"},{"name":"School of Pharmacy Provincial Key Laboratory of Inflammation and Molecular Drug Target Institute for Translational Neuroscience Affiliated Hospital 2 of Nantong University Centre for Neural Developmental and Degenerative Research Nantong University  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9411-9517","authenticated-orcid":false,"given":"Qing","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Pharmacy Provincial Key Laboratory of Inflammation and Molecular Drug Target Institute for Translational Neuroscience Affiliated Hospital 2 of Nantong University Centre for Neural Developmental and Degenerative Research Nantong University  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinwen","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, the Key Laboratory of Smart Drug Delivery (Ministry of Education), School of Pharmacy Minhang Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Zhun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, the Key Laboratory of Smart Drug Delivery (Ministry of Education), School of Pharmacy Minhang Hospital Fudan University  Shanghai China"},{"name":"School of Pharmacy and Laboratory of Drug Discovery from Natural Resources and Industrializtion Macau University of Science and Technology  Macau China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0035-148X","authenticated-orcid":false,"given":"Yicheng","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, the Key Laboratory of Smart Drug Delivery (Ministry of Education), School of Pharmacy Minhang Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000004597"},{"issue":"10","key":"e_1_2_9_3_1","article-title":"Overview of Acute Ischemic Stroke Evaluation and Management","volume":"9","author":"Hasan T. 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