{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:17:34Z","timestamp":1790291854628,"version":"4.1.0"},"reference-count":167,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005089","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["583003"],"award-info":[{"award-number":["583003"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission, Adminitrative Commission of Zhongguancun Science Park","doi-asserted-by":"publisher","award":["Z191199996619048"],"award-info":[{"award-number":["Z191199996619048"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission, Adminitrative Commission of Zhongguancun Science Park","doi-asserted-by":"publisher","award":["L212007"],"award-info":[{"award-number":["L212007"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Spinal cord injury (SCI) is a complex central nervous system disorder characterized by multifaceted pathological processes, including inflammation, oxidative stress, programmed cell death, autophagy, and mitochondrial dysfunction. Sirtuin 1 (Sirt1), a critical NAD\n                      <jats:sup>+<\/jats:sup>\n                      \u2010dependent deacetylase, has emerged as a promising therapeutic target for SCI repair due to its potential to protect neurons, regulate glial and vascular cells, and optimize the injury microenvironment. However, the regulatory roles of Sirt1 in SCI are complex and challenging, as its effects vary depending on activation timing, expression levels, and cell types.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic literature review was conducted using PubMed, Scopus, and Web of Science to identify studies investigating Sirt1 in SCI. Relevant publications were analyzed to synthesize current evidence on Sirt1's mechanisms, therapeutic effects, and challenges in SCI repair.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sirt1 exerts broad regulatory effects across diverse pathological processes and cell types post\u2010SCI. It promotes neuronal survival and axonal regeneration, modulates astrocytes and microglia to resolve inflammation, supports oligodendrocyte\u2010mediated myelination, and enhances vascular endothelial function. Proper Sirt1 activation may mitigate secondary injury, whereas excessive or prolonged activation could impair inflammatory resolution or disrupt cellular homeostasis. This review highlights Sirt1 activation as potential therapies, but challenges include optimizing spatiotemporal activation and addressing dual roles in different cell types.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Targeting Sirt1 represents a viable strategy for SCI repair, given its multifaceted regulation of neuroprotection, immunomodulation, and tissue remodeling. However, translating these findings into therapies requires resolving critical issues such as cell type\u2010specific delivery, precise activation timing, and dosage control. This review provides a theoretical foundation and practical insights for advancing Sirt1\u2010based treatments for SCI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.70244","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T23:34:47Z","timestamp":1738884887000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Sirtuin1 in Spinal Cord Injury: Regulatory Mechanisms, Microenvironment Remodeling and Therapeutic Potential"],"prefix":"10.1111","volume":"31","author":[{"given":"Jinze","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Xuanwu Hospital, Capital Medical University  Beijing China"},{"name":"Spine Center China International Neuroscience Institute (CHINA\u2010INI)  Beijing China"},{"name":"Lab of Spinal Cord Injury and Functional Reconstruction China International Neuroscience Institute (CHINA\u2010INI), Xuanwu Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengyu","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Xuanwu Hospital, Capital Medical University  Beijing China"},{"name":"Spine Center China International Neuroscience Institute (CHINA\u2010INI)  Beijing China"},{"name":"Lab of Spinal Cord Injury and Functional Reconstruction China International Neuroscience Institute (CHINA\u2010INI), Xuanwu Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqiu","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Integrative Medicine, Beijing Ditan Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Zhang","sequence":"additional","affiliation":[{"name":"Lab of Spinal Cord Injury and Functional Reconstruction China International Neuroscience Institute (CHINA\u2010INI), Xuanwu Hospital, Capital Medical University  Beijing China"},{"name":"Department of Neurosurgery The First Hospital of Hebei Medical University  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Xuanwu Hospital, Capital Medical University  Beijing China"},{"name":"Spine Center China International Neuroscience Institute (CHINA\u2010INI)  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7860-278X","authenticated-orcid":false,"given":"Fengzeng","family":"Jian","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Xuanwu Hospital, Capital Medical University  Beijing China"},{"name":"Spine Center China International Neuroscience Institute (CHINA\u2010INI)  Beijing China"},{"name":"Lab of Spinal Cord Injury and Functional Reconstruction China International Neuroscience Institute (CHINA\u2010INI), Xuanwu Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/10790268.2016.1210925"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2006.12.005"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2009.0888"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102023\u2010075049"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750\u20103639.1995.tb00619.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(02)07603\u20101"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0963689718755778"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010023\u201001477\u20106"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13144101"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2020.09.014"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11070987"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.1261288"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/nrr.Nrr\u2010d\u201023\u201001848"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311\u2010014\u20100299\u20105"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2023.4983"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2023.1228761"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.886087"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010015\u20109158\u20106"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119803"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2012.10.525"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.568861"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010023\u201003364\u20101"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2022.01.016"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2021.06.025"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010024\u201004408\u2010w"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12964"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.111686"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.3046\u201016.2017"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102615"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.134120"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.irn.2019.05.001"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.13838"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2021.136151"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010024\u201005089\u20108"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010023\u201002217\u20102"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2023.10.010"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2024.1405546"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010018\u20101151\u20103"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2023.1172091"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.204989"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2023.107202"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2023.114658"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102767"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.15904"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00778"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2021.11.001"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.2271"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673\u20105374.380905"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1080\/00207454.2023.2285707"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1177\/15459683231183716"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8010670"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413\u2010022\u201000199\u20109"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8111354"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010024\u201004188\u20103"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2022.108178"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.30377"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2017.02.027"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2018.06.018"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2019.05.005"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.22038\/ijbms.2020.44534.10416"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103420"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.22038\/ijbms.2017.9272"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.31083\/j.jin2206153"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673\u20105374.369094"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2016.06.006"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1097\/cm9.0000000000003032"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210\u2010024\u201003319\u2010w"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159x20666221012122855"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2023.1228968"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2023.01.009"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010022\u201002632\u20106"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2016.02.011"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3293"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2010.09.005"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1177\/1535370214557218"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107141"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2009.101"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0b013e328328d0a4"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155529"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2021.09.017"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2023.107037"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010018\u20101345\u20108"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753\u2010021\u201001476\u20101"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.602417"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202584"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2023.105535"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103542"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567202618666211109104419"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2018.10.031"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.92222"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1073689"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6782872"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10529\u2010020\u201002939\u20105"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2017.09.037"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2009.12.032"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjad075"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111549"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.109120"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.4425"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e328354256c"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673\u20105374.374136"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.11.017"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aanat.2019.01.015"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2019.1667189"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.3171\/2016.11.Jns162121"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.156120"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031\u2010021\u201001908\u20105"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858408331372"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac235"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1190927"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2024.1404463"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.619707"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13866"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011\u2010020\u201000597\u20100"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12264\u2010024\u201001258\u20103"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.31083\/j.fbl2903094"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064\u2010022\u201003820\u20109"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2022.2053032"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031\u2010016\u20100849\u2010x"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571\u2010022\u201001288\u20103"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1039\/c7fo01442b"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1097\/wnr.0000000000001293"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22421"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2020.7413"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws171"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.109.864629"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09917"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2018.09.006"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929\u2010019\u20100529\u20106"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes14122155"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/9013169"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401\u2010020\u20100386\u20106"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2024.114253"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16081057"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1590\/1414\u2010431x20177319"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2019.4106"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1419390"},{"key":"e_1_2_10_139_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14764"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.84133"},{"key":"e_1_2_10_141_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad392"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010017\u20100841\u20106"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010020\u201002000\u20102"},{"key":"e_1_2_10_144_1","doi-asserted-by":"publisher","DOI":"10.2147\/sccaa.S173852"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.05.048"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1334828"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0006\u20108993(97)00381\u20108"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2016.34"},{"key":"e_1_2_10_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2015.01.029"},{"key":"e_1_2_10_150_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10060973"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010019\u201001861\u2010w"},{"key":"e_1_2_10_152_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232112994"},{"key":"e_1_2_10_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2023.114551"},{"key":"e_1_2_10_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.112529"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2010.58"},{"key":"e_1_2_10_156_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3nr00957b"},{"key":"e_1_2_10_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0079\u20106123(00)28005\u20109"},{"key":"e_1_2_10_158_1","doi-asserted-by":"publisher","DOI":"10.2337\/db21\u20100147"},{"key":"e_1_2_10_159_1","doi-asserted-by":"publisher","DOI":"10.2174\/138945012799201711"},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18030548"},{"key":"e_1_2_10_161_1","doi-asserted-by":"publisher","DOI":"10.2174\/156720211798121007"},{"key":"e_1_2_10_162_1","doi-asserted-by":"publisher","DOI":"10.1385\/jmn:21:2:173"},{"key":"e_1_2_10_163_1","doi-asserted-by":"publisher","DOI":"10.3109\/10611860903434001"},{"key":"e_1_2_10_164_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40820\u2010019\u20100252\u20106"},{"key":"e_1_2_10_165_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384047.2023.2235770"},{"key":"e_1_2_10_166_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0b013e32834d813b"},{"key":"e_1_2_10_167_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20133153"},{"key":"e_1_2_10_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2013.06.007"}],"container-title":["CNS Neuroscience &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cns.70244","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cns.70244","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cns.70244","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:47:56Z","timestamp":1777902476000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cns.70244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":167,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1111\/cns.70244"],"URL":"https:\/\/doi.org\/10.1111\/cns.70244","archive":["Portico"],"relation":{},"ISSN":["1755-5930","1755-5949"],"issn-type":[{"value":"1755-5930","type":"print"},{"value":"1755-5949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"2024-09-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70244"}}