{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T01:19:01Z","timestamp":1784078341859,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:00:00Z","timestamp":1742256000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2408800"],"award-info":[{"award-number":["2022YFC2408800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["Z240021"],"award-info":[{"award-number":["Z240021"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172021"],"award-info":[{"award-number":["82172021"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371305"],"award-info":[{"award-number":["82371305"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2023ZD0505306"],"award-info":[{"award-number":["2023ZD0505306"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To explore the role of transcranial Doppler (TCD) parameters after encephaloduroarteriosynangiosis (EDAS) to identify collateral development in moyamoya disease (MMD) and assess the relationship between these collateral formations and long\u2010term postoperative cerebrovascular events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of 91\u2009MMD patients who underwent EDAS. Patients were categorized into rich or poor collateral groups based on postoperative angiography. TCD was used to monitor changes in hemodynamic parameters pre\u2010and post\u2010surgery. The association between clinical outcome, TCD parameters, and the degree of collateral development was investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Outcomes<\/jats:title><jats:p>Ninety\u2010one patients were assessed, with 45 (49.0%) exhibiting rich collaterals and 46 (51.0%) showing poor collaterals. Over 2\u2009years, the rich collateral group experienced significantly fewer cerebrovascular events than the poor collateral group (<jats:italic>p<\/jats:italic>\u2009=\u20090.041). Postoperative evaluations demonstrated significant improvements in hemodynamic parameters within the rich collateral group, including increases in peak\u2010systolic velocity (PSV), end\u2010diastolic velocity (EDV), and mean velocity (MV), alongside decreases in resistance index (RI) and pulsatility index (PI) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). An EDV cutoff of &gt;\u200916.62\u2009cm\/s in the superficial temporal artery (STA) effectively identified collateral development, yielding an area under the curve (AUC) of 0.907. Additionally, multivariate analysis revealed a strong association between preoperative MV of the STA and collateral formation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TCD sonography is a non\u2010invasive modality essential for assessing cerebral hemodynamics after revascularization in MMD. Collateral development shown on angiography corresponds to hemodynamic changes reflected in TCD. The postoperative EDV of the STA was a vital indicator of effective collaterals. Patients with well\u2010developed collaterals were at a lower risk of long\u2010term cerebrovascular events post\u2010surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.70245","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T05:20:25Z","timestamp":1742361625000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Role of TCD in Assessing Postoperative Collateral Development and Long\u2010Term Clinical Outcome in Moyamoya Disease"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4337-8681","authenticated-orcid":false,"given":"Shuangfeng","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songtao","family":"Pei","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Fifth Medical Center of Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqin","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Fifth Medical Center of Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3651-4383","authenticated-orcid":false,"given":"Jiali","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Beijing Shijitan Hospital Affiliated to Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanjing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heguan","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery First Medical Center of Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhong","family":"Ren","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hypoxic Conditioning Translational Medicine, Xuanwu Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0293-2744","authenticated-orcid":false,"given":"Xunming","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"Department of Emergency, Xuanwu Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Fifth Medical Center of Chinese PLA General Hospital  Beijing China"},{"name":"Department of Neurosurgery First Medical Center of Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,18]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804622"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/str.0000000000000443"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/bc.bc_37_24"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.2176\/jns\u2010nmc.2021\u20100382"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3171\/2016.11.Jns161688"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330\u2010021\u201007960\u20104"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/bc.bc_20_22"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3171\/2014.8.Jns132176"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000120172"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0188948"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.976695"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330\u2010020\u201007479\u20100"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2015.01739"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41016\u2010022\u201000300\u20105"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.14336\/ad.2023.0731"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.52.245"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41016\u2010023\u201000318\u20103"},{"issue":"2","key":"e_1_2_12_19_1","first-page":"158","article-title":"Inflammation, Immunity, and Hypertension","volume":"49","author":"Agita A.","year":"2017","journal-title":"Acta Medica Indonesiana"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1227\/00006123\u2010199209000\u201000003"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.122.039975"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.3171\/2017.5.Jns17353"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.3171\/2018.9.Jns181562"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2511080654"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.3171\/2024.2.Jns24208"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12519\u2010024\u201000824\u2010z"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.4103\/bc.bc_57_22"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.902474"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.14336\/ad.2022.0427"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/23969873221144089"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2024.05.025"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2022.120408"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2019.04.214"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.3171\/2018.6.Peds18151"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanwpc.2021.100331"}],"container-title":["CNS Neuroscience &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cns.70245","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T15:53:50Z","timestamp":1744818830000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cns.70245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/cns.70245"],"URL":"https:\/\/doi.org\/10.1111\/cns.70245","archive":["Portico"],"relation":{},"ISSN":["1755-5930","1755-5949"],"issn-type":[{"value":"1755-5930","type":"print"},{"value":"1755-5949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"2024-11-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70245"}}