{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T14:41:26Z","timestamp":1754145686615,"version":"3.41.2"},"reference-count":70,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82020108013","82327809"],"award-info":[{"award-number":["82020108013","82327809"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Glucose metabolism and plasma biomarkers have emerged as important early markers in Alzheimer's disease. Different subtypes (single memory domain, multidomain) of subjective cognitive decline (SCD) may represent distinct stages of disease progression, but the differences in glucose metabolism remain unclear. This study focused on exploring the differences in glucose metabolism between different SCD subtypes and the correlation with plasma biomarkers based on <jats:sup>18<\/jats:sup>F\u2010FDG PET.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, thirty\u2010three normal controls (NCs), thirty\u2010five individuals with single memory domain SCD (sd\u2010SCD), thirty\u2010nine individuals with multidomain SCD (md\u2010SCD), and twenty\u2010one cognitively impaired (CI) individuals were involved. We investigated the standardized\u00a0uptake value ratio (SUVR) and voxel differences between the sd\u2010SCD and md\u2010SCD groups followed by FDR and GRF corrections, with an average follow\u2010up time of 44.98\u2009\u00b1\u200916.49\u2009months. Correlation analyses were employed to assess relationships between FDG\u2010PET SUVR and neuropsychological scales as well as plasma biomarkers. Finally, Kaplan\u2013Meier survival analysis was used to investigate the risk of cognitive decline conversion among SCD subgroups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After controlling for the effects of covariates, the following brain regions showed voxel differences and lower SUVR in md\u2010SCD groups, including right anterior cingulate and paracingulate gyri (ACG.R, <jats:italic>p\u2009=<\/jats:italic>\u20090.003), left anterior cingulate and paracingulate gyri (ACG.L, <jats:italic>p\u2009=<\/jats:italic>\u20090.003), right middle temporal gyrus (MTG.R, <jats:italic>p\u2009=<\/jats:italic>\u20090.004), and right inferior temporal gyrus (ITG.R, <jats:italic>p\u2009=<\/jats:italic>\u20090.001), compared to the sd\u2010SCD group. SUVR of ACG.R was correlated with plasma A\u03b242\/40 (<jats:italic>r<\/jats:italic>\u2009=\u20090.435, <jats:italic>p<\/jats:italic>\u2009=\u20090.006) and AVLT\u2010N7 score (<jats:italic>r<\/jats:italic>\u2009=\u20090.347, <jats:italic>p<\/jats:italic>\u2009=\u20090.031) in the md\u2010SCD group while none of the correlations existed in the sd\u2010SCD group. SUVR of MTG.R was also correlated with the AVLT\u2010N7 score (<jats:italic>r<\/jats:italic>\u2009=\u20090.246, <jats:italic>p<\/jats:italic>\u2009=\u20090.035) across SCD individuals. The SCD individuals with positive plasma A\u03b242\/40, p\u2010tau181, and glucose metabolism in above four regions, or those in the md\u2010SCD group showed an elevated risk of cognitive conversion in comparison to the controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Differences in glucose metabolism could be observed between the md\u2010SCD and sd\u2010SCD groups. SCD participants in the md\u2010SCD group, or those with positive biomarkers, might represent a higher risk of cognitive decline\u00a0conversion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.70264","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T23:44:07Z","timestamp":1748389447000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Differences in Glucose Metabolism Between Single Memory Domain and Multidomain Subjective Cognitive Decline: A Longitudinal Study From <scp>SILCODE<\/scp>"],"prefix":"10.1111","volume":"31","author":[{"given":"Min","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Neurology Xuanwu Hospital of Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luyao","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering, School of Life Sciences 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