{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:26:04Z","timestamp":1791411964244,"version":"4.3.3"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T00:00:00Z","timestamp":1739404800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LQ21H090008"],"award-info":[{"award-number":["LQ21H090008"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017531","name":"Medical and Health Research Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2021434317"],"award-info":[{"award-number":["2021434317"]}],"id":[{"id":"10.13039\/501100017531","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The coagulation system is intrinsically linked to pathological mechanisms and progression of ischemic stroke. However, the role of preoperative coagulation function in determining the functional outcomes of acute ischemic stroke patients following large artery occlusion (AIS\u2010LVO) has not been extensively evaluated in peer\u2010reviewed literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We utilized logistic regression analyses, complemented by the construction of receiver operating characteristic (ROC) curves, to identify significant predictive factors for poor prognosis following endovascular thrombectomy (EVT). Additionally, subgroup analyses were conducted to further assess the prognostic efficacy of coagulation function across different subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 607 patients were enrolled, with 335 (55.19%) experiencing an unfavorable outcome. Multivariate regression analysis identified preoperative D\u2010dimer and PTA as independent predictors of 3\u2010month prognosis. After adjusting for confounders, elevated preoperative D\u2010dimer levels (\u2265\u2009715\u2009mg\/L), identified by cut\u2010off value, were a significant predictor of poor prognosis, with 2.51\u2010fold higher risk compared to the normal range. Conversely, elevated PTA levels (\u2265\u200985.5%) were significantly and inversely associated with poor prognosis, indicating a reduced risk of 0.39 times. Furthermore, the combination of elevated D\u2010dimer and reduced PTA demonstrated a synergistic effect, markedly increasing the risk of poor outcomes in AIS\u2010LVO patients. Subgroup analyses revealed that failed recanalization, comorbid diabetes, and non\u2013middle cerebral artery (MCA) occlusion significantly influence the predictive value of D\u2010dimer and PTA for clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Elevated admission D\u2010dimer and reduced PTA levels are independent predictors of poor prognosis in patients with AIS\u2010LVO, and there is a synergistic interaction between the two variables.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.70267","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T05:59:11Z","timestamp":1739426351000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Emergency Admission Plasma D\u2010Dimer and Prothrombin Activity: Novel Predictors for Clinical Outcomes After Thrombectomy in Acute Ischemic Stroke With Large Artery Occlusion"],"prefix":"10.1111","volume":"31","author":[{"given":"Shandong","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery The Second Affiliated Hospital of Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peizheng","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery The Second Affiliated Hospital of Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linxin","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery The Second Affiliated Hospital of Zhejiang University School of Medicine  Hangzhou 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