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The pyrosequencing results further revealed hypomethylation of DAB2IP and hypermethylation of SMYD3. Moreover, we verified the upregulation of DAB2IP expression accompanied by the downregulation of SMYD3 expression in the DEACMP rats model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study, based on dysregulated DNA methylation and gene expression profiles, identified and validated two DEACMP\u2010related genes (DAB2IP and SMYD3) that could serve as epigenetic biomarkers and potential therapeutic targets for DEACMP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.70270","type":"journal-article","created":{"date-parts":[[2025,2,15]],"date-time":"2025-02-15T03:16:01Z","timestamp":1739589361000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Integration of Methylation and Gene Expression Deciphered Candidate Biomarkers\n                    <scp>DAB2IP<\/scp>\n                    and\n                    <scp>SMYD3<\/scp>\n                    in Delayed Encephalopathy After Carbon Monoxide Poisoning"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4185-0506","authenticated-orcid":false,"given":"Hongyi","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine The First Affiliated Hospital of Zhengzhou University, Medical Key Laboratory of Poisoning Diseases of Henan Province  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ding","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine The First Affiliated Hospital of Zhengzhou University, Medical Key Laboratory of Poisoning Diseases of Henan Province  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine The First Affiliated Hospital of 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