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Additionally, by utilizing cognitive probabilistic maps from Neurosynth and gene expression data from the Allen Human Brain Atlas, we applied partial least\u2010squares regression analysis to identify the neurocognitive and transcriptional correlates of these RNS changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After SD, older participants exhibited decreased RNS in the default mode network (DMN) and dorsal attention network, with increased RNS in the visual network. Young participants also showed decreased RNS in the DMN, notably in the left inferior parietal lobe, left dorsolateral prefrontal cortex, and left posterior cingulate cortex. In young participants, SD\u2010induced RNS changes significantly correlated with cognitive processes such as \u201cattention,\u201d \u201ccognitive control,\u201d and \u201cworking memory,\u201d while in older participants, they correlated with \u201clearning,\u201d \u201cfocus,\u201d and \u201cdecision.\u201d Gene\u2010category enrichment analysis indicated that specific genes related to signal transduction, ion channels, and immune signaling might influence SD pathophysiology by affecting functional connectivity in young participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study elucidates shared and age\u2010specific brain functional network alterations associated with SD, providing a neurocognitive and molecular basis for understanding the underlying pathophysiology.<\/jats:p>\n                  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