{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:13:09Z","timestamp":1790107989772,"version":"4.0.1"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T00:00:00Z","timestamp":1739836800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100030847","name":"Georgia Tech 3D Systems Packaging Research Center","doi-asserted-by":"publisher","award":["82271546and82371511"],"award-info":[{"award-number":["82271546and82371511"]}],"id":[{"id":"10.13039\/100030847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      We initiated an exploration of the relationship between hydrogen sulfide (H\n                      <jats:sub>2<\/jats:sub>\n                      S) and Schizophrenia (SZ) as well as its mechanism at the three levels of population study, cellular investigation, and animal model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Clinical data and peripheral blood samples from 78 patients with SZ and 83 healthy controls (HC) were collected for the detection of H\n                      <jats:sub>2<\/jats:sub>\n                      S levels (ChiCTR (Chinese Clinical Trial Registry) 900026776). MK801 (Dizocilpine) was used to establish SZ models in cells and rats, with sodium hydrosulfide (NaHS) serving as an exogenous H\n                      <jats:sub>2<\/jats:sub>\n                      S donor. H\n                      <jats:sub>2<\/jats:sub>\n                      S levels in plasma and hippocampal tissue of rats were measured using Enzyme Linked Immunosorbent Assay (ELISA). Terminal dUTP Nick End Labeling (TUNEL) staining was employed to detect apoptosis, enzyme activity was determined to assess apoptotic protease activity, neuron damage was identified by Nissl staining, and the protein S\u2010sulfhydrylation test was utilized to evaluate alterations in apoptosis\u2010associated protein S\u2010sulfhydrylation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      H\n                      <jats:sub>2<\/jats:sub>\n                      S content significantly decreased in the plasma of SZ patients and in the plasma and hippocampal tissue of SZ model rats. NaHS pretreatment reduced MK801\u2010induced apoptosis in SH\u2010SY5Y cells. SZ model rats exhibited increased behavioral abnormalities, hippocampal apoptosis, and reduced S\u2010sulfhydrylation of an apoptosis\u2010related protein, both restored after NaHS pretreatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      H\n                      <jats:sub>2<\/jats:sub>\n                      S content is significantly reduced in SZ, and supplementation of H\n                      <jats:sub>2<\/jats:sub>\n                      S can alleviate SZ\u2010like behavior by inducing S\u2010sulfhydration of apoptotic proteins.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.70278","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T05:45:59Z","timestamp":1739857559000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Hydrogen Sulfide Alleviates Schizophrenia\u2010Like Behavior Through Regulating Apoptosis by S\u2010Sulfhydrylation Modification"],"prefix":"10.1111","volume":"31","author":[{"given":"Xinzhe","family":"Du","sequence":"first","affiliation":[{"name":"Department of Psychiatry First Hospital of Shanxi Medical University  Taiyuan Shanxi China"},{"name":"Shanxi Key Laboratory of Artificial Intelligence Assisted Diagnosis and Treatment for Mental Disorder First Hospital of Shanxi Medical University  Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Hu","sequence":"additional","affiliation":[{"name":"Basic Medical College Shanxi Medical University  Taiyuan Shanxi 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