{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T03:10:43Z","timestamp":1773112243695,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2025,4]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n This study examines how anatomical variations influence the targeting coordinates of the subthalamic nucleus (STN) in patients with Idiopathic Parkinson's Disease (IPD) undergoing Deep Brain Stimulation (DBS), with the goal of enhancing targeting accuracy.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A retrospective analysis was performed on 202 STNs from patients who received bilateral STN\u2010DBS surgery. Pre\u2010 and postoperative imaging data were used to determine accurate STN coordinates, while brain volume measurements, ventricle size, Evans Index, and AC \u2013PC length were analyzed. Atrophy grading scales were also applied. Correlation and regression analyses assessed the relationship between the STN target location and all anatomical parameters on the\n x<\/jats:italic>\n ,\n y<\/jats:italic>\n , and\n z<\/jats:italic>\n axes.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Age showed a significant positive correlation with lateral STN coordinate shift on the\n x<\/jats:italic>\n \u2010axis, with each additional year leading to a 0.046\u2009mm shift. An increase in peripheral gray matter volume and a decrease in white matter volume were significantly associated with the lateral displacement of the STN. Total ventricle volume demonstrated a positive correlation with STN shift on both the\n x<\/jats:italic>\n \u2010axis (0.0227\u2009mm per cm\n 3<\/jats:sup>\n increase) and\n z<\/jats:italic>\n \u2010axis (0.0087\u2009mm per cm\n 3<\/jats:sup>\n increase). Significant correlations were also found for the Evans Index with lateral shift on the\n x<\/jats:italic>\n \u2010axis and for AC\u2010PC length with vertical shifts.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Anatomical factors, such as brain volume, ventricle size, Evans Index, AC\u2010PC length, and atrophy scores, significantly influence STN localization in PD patients undergoing DBS. Accounting for these shifts during surgical planning may improve electrode placement accuracy and enhance therapeutic outcomes, underscoring the importance of personalized targeting strategies.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cns.70307","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T01:41:09Z","timestamp":1745545269000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anatomical Determinants of\n STN<\/scp>\n Coordinate Shift in Idiopathic Parkinson's Disease\n DBS<\/scp>\n Surgery"],"prefix":"10.1111","volume":"31","author":[{"given":"Ozan","family":"Hasimoglu","sequence":"first","affiliation":[{"name":"Neurosurgery Department, University of Health Sciences, Hamidiye Faculty of Medicine, Basaksehir Cam and Sakura City Hospital Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuba \u00d6zge","family":"Kara\u00e7oban","sequence":"additional","affiliation":[{"name":"Neurology Department, University of Health Sciences, Hamidiye Faculty of Medicine, Basaksehir Cam and Sakura City Hospital Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5517-4735","authenticated-orcid":false,"given":"Taha","family":"Hanoglu","sequence":"additional","affiliation":[{"name":"Neurosurgery Department, University of Health Sciences, Hamidiye Faculty of Medicine, Basaksehir Cam and Sakura City Hospital Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nur Bahar","family":"Geylan","sequence":"additional","affiliation":[{"name":"Neurosurgery Department, University of Health Sciences, Hamidiye Faculty of Medicine, Basaksehir Cam and Sakura City Hospital Istanbul 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