{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:29:22Z","timestamp":1753878562576,"version":"3.41.2"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671258","81901297"],"award-info":[{"award-number":["81671258","81901297"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the differences in gait parameters and cortical activity during a single\u2010task walking (STW) and cognitive dual\u2010task walking (DTW) between multiple system atrophy with predominant parkinsonism (MSA\u2010P) and Parkinson's disease (PD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>24 MSA\u2010P patients, 20 PD patients, and 22 healthy controls (HCs) were enrolled. Gait parameters were collected using a portable inertial measurement unit system, and the relative change of oxyhemoglobin (\u0394HbO<jats:sub>2<\/jats:sub>) in the bilateral frontal and sensorimotor cortex was obtained by functional near\u2010infrared spectroscopy during walking with and without cognitive tasks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MSA\u2010P patients had increased step length variability and higher \u0394HbO<jats:sub>2<\/jats:sub> in the right dorsolateral prefrontal cortex (DLPFC), relative to PD patients and HCs during the DTW condition. Meanwhile, MSA\u2010P patients exhibited higher step length variability and \u0394HbO<jats:sub>2<\/jats:sub> in the right DLPFC during DTW compared to STW. Furthermore, mild negative correlations were found between the \u0394HbO<jats:sub>2<\/jats:sub> in the right DLPFC and step length, while there was a mild positive correlation between \u0394HbO<jats:sub>2<\/jats:sub> and step length variability during the DTW condition. Notably, receiver operating characteristic (ROC) curve analysis uncovered that the areas under the curve (AUCs) of the \u0394HbO<jats:sub>2<\/jats:sub> of the right DLPFC and step length variability during DTW were 0.798 (95% confidence interval [CI]: 0.651\u20130.945, sensitivity\u2009=\u20090.650, specificity\u2009=\u20090.958) and 0.721 (95% CI: 0.570\u20130.871, sensitivity\u2009=\u20090.625, specificity\u2009=\u20090.800), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MSA\u2010P patients demonstrate more severe gait disturbance and increased DLPFC activity compared with PD patients and HCs. Gait parameters and cortical activity could be a potential features discerning MSA\u2010P patients and PD patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cns.70342","type":"journal-article","created":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T05:00:29Z","timestamp":1743224429000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Differences Between Patients With Multiple System Atrophy With Predominant Parkinsonism and Parkinson's Disease Based on fNIRS and Gait Analysis"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8303-9020","authenticated-orcid":false,"given":"Mengxi","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Nanjing Medical University  Nanjing 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