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Restoring these oscillations may be crucial for rescuing cognitive functions. Low\u2010intensity transcranial ultrasound stimulation (TUS), a noninvasive neuromodulation method, offers high spatial resolution and deep penetration. However, it remains unclear how 40\u2009Hz and 200\u2009Hz TUS may improve memory in AD by regulating hippocampal oscillations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We applied 40\u2009Hz and 200\u2009Hz TUS to the CA1 region of AD mice, performing memory assessments and CA1 electrophysiology recordings simultaneously.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our results showed that both 40\u2009Hz and 200\u2009Hz TUS significantly improved memory performance in AD mice by targeting the dorsal hippocampus and increasing power in corresponding frequency bands. Specifically, 40\u2009Hz TUS enhanced gamma and ripple bands, while 200\u2009Hz TUS strongly affected both. This enhancement increased during stimulation and persisted 5\u2009days poststimulation. Improved coupling between theta and gamma oscillations indicated better hippocampal coordination with other brain regions. Additionally, 40\u2009Hz TUS raised sharp wave ripple (SPW\u2010Rs) incidence, and 200\u2009Hz TUS increased both SPW\u2010R incidence and duration, contributing to memory improvement. Behavioral performance significantly improved with TUS at both frequencies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Ultrasound\u2010induced synchronized neural activities at 40\u2009Hz and 200\u2009Hz entrained corresponding oscillations and improved memory in Alzheimer's disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.70351","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T06:52:01Z","timestamp":1744181521000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Ultrasound\u2010Induced Synchronized Neural Activities at\n                    <scp>40\u2009Hz<\/scp>\n                    and\n                    <scp>200\u2009Hz<\/scp>\n                    Entrained Corresponded Oscillations and Improve Alzheimer's Disease Memory"],"prefix":"10.1111","volume":"31","author":[{"given":"Jiamin","family":"Chen","sequence":"first","affiliation":[{"name":"School of Electrical Engineering Yanshan University  Qinhuangdao China"},{"name":"Key Laboratory of Intelligent Rehabilitation and Neuromodulation of Hebei Province Yanshan University  Qinhuangdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingran","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Electrical Engineering Yanshan University  Qinhuangdao China"},{"name":"Key Laboratory of Intelligent Rehabilitation and Neuromodulation of Hebei Province Yanshan University  Qinhuangdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"School of Electrical Engineering Yanshan University  Qinhuangdao China"},{"name":"Key Laboratory of Intelligent Rehabilitation and Neuromodulation of Hebei Province Yanshan University  Qinhuangdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Li","sequence":"additional","affiliation":[{"name":"Guangdong Artificial Intelligence and Digital Economy Laboratory (Guangzhou)  Guangzhou China"},{"name":"School of Automation Science and Engineering South China University of Technology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Neuroscience Institute, NYU Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8951-810X","authenticated-orcid":false,"given":"Yi","family":"Yuan","sequence":"additional","affiliation":[{"name":"School of Electrical Engineering Yanshan University  Qinhuangdao China"},{"name":"Key Laboratory of Intelligent Rehabilitation and Neuromodulation of Hebei Province Yanshan University  Qinhuangdao 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