{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T21:39:03Z","timestamp":1784842743209,"version":"3.55.0"},"reference-count":58,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:00:00Z","timestamp":1744156800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82474616"],"award-info":[{"award-number":["82474616"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Umbilical cord\u2010derived mesenchymal stem cells (UCMSCs) have emerged as a promising treatment for ischemic stroke. This study aimed to evaluate the therapeutic efficacy and potential mechanisms of UCMSCs in treating ischemic stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search of PubMed, Web of Science, and Embase was conducted up to April 25, 2024. Literature was screened based on the PICOS principle, with predefined inclusion and exclusion criteria. Relevant data were extracted and analyzed using Review Manager 5.4.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Out of 1390 retrieved articles, 30 were included in the meta\u2010analysis. UCMSCs significantly reduced infarct size and volume, improved neurological deficit scores, and facilitated neurobehavioral recovery. UCMSCs treatment also modulated inflammatory cytokine levels in brain tissue and serum, promoted microglial polarization, inhibited apoptosis, and increased vessel density in the peri\u2010infarct tissue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>UCMSCs administration significantly promoted the neurological function recovery after ischemic stroke. Their mechanisms of action may be related to immune response regulation, inhibition of apoptosis, and promotion of angiogenesis. These findings provide theoretical guidance for improving the quality of basic research and clinical translation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.70357","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T06:23:42Z","timestamp":1744179822000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy and Potential Mechanisms of Umbilical Cord\u2010Derived Mesenchymal Stem Cells in the Treatment of Ischemic Stroke in Animal Models: A Meta\u2010Analysis"],"prefix":"10.1111","volume":"31","author":[{"given":"Renli","family":"Wei","sequence":"first","affiliation":[{"name":"Fujian Key Laboratory of Aptamers Technology Fuzhou General Teaching Hospital (The 900th Hospital), Fujian University of Traditional Chinese Medicine  Fuzhou Fujian China"},{"name":"College of Rehabilitation Medicine Fujian University of Traditional Chinese Medicine  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minguang","family":"Yang","sequence":"additional","affiliation":[{"name":"The Institute of Rehabilitation Industry Fujian University of Traditional Chinese Medicine  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine Fuzhou General Clinical Medical School, Fujian Medical University  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqian","family":"Qiu","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Aptamers Technology Fuzhou General Teaching Hospital (The 900th Hospital), Fujian University of Traditional Chinese Medicine  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Fan","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Aptamers Technology Fuzhou General Teaching Hospital (The 900th Hospital), Fujian University of Traditional Chinese Medicine  Fuzhou Fujian China"},{"name":"College of Rehabilitation Medicine Fujian University of Traditional Chinese Medicine  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muxuan","family":"Fang","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Aptamers Technology Fuzhou General Teaching Hospital (The 900th Hospital), Fujian University of Traditional Chinese Medicine  Fuzhou Fujian China"},{"name":"College of Rehabilitation Medicine Fujian University of Traditional Chinese Medicine  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Aptamers Technology 900th Hospital of Joint Logistics Support Force, People's Liberation Army (PLA)  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaojie","family":"Cheng","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Aptamers Technology 900th Hospital of Joint Logistics Support Force, People's Liberation Army (PLA)  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhong","family":"Li","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Aptamers Technology Fuzhou General Teaching Hospital (The 900th Hospital), Fujian University of Traditional Chinese Medicine  Fuzhou Fujian China"},{"name":"College of Rehabilitation Medicine Fujian University of Traditional Chinese Medicine  Fuzhou Fujian China"},{"name":"Fujian Key Laboratory of Aptamers Technology 900th Hospital of Joint Logistics Support Force, People's Liberation Army (PLA)  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1602-7681","authenticated-orcid":false,"given":"Shenghang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Aptamers Technology Fuzhou General Teaching Hospital (The 900th Hospital), Fujian University of Traditional Chinese Medicine  Fuzhou Fujian China"},{"name":"Fujian Key Laboratory of Aptamers Technology 900th Hospital of Joint Logistics Support Force, People's Liberation Army (PLA)  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00642-1"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25105252"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25126297"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(18)30500\u20103"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3171\/2023.2.JNS222807"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.0589"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(22)00519\u20101"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202002944"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.19\u20100430"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.570179"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.2217\/rme-2019-0119"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23063149"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2014.10.065"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.603621"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1095469"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1051831"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975\u2010019\u201000736\u20105"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102288\u201014\u201043"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.105298"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.14348\/molcells.2016.2317"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2018.04.004"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2007.06.010"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/scrt434"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.06.087"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074478"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.5582\/irdr.2015.01010"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010023\u201002738\u20105"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318195742e"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/0963689717728936"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010023\u201003779\u2010w"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368910X507204"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.546659"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-018-0041-1"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011\u2010016\u20109897\u20108"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2015.04.049"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.13400"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00133"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.11553"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/0963689718802754"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14412"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.593129"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673\u20105374.211189"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.01.038"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756286419859725"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.927"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883\u2010020\u201001865\u20103"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000278"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1136\/svn\u20102020\u2010000834"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40883\u2010021\u201000242\u2010x"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2016.05.001"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1047550"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231710023"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2020.06.009"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2019.134346"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-023-01061-2"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.27297"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076389"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.4252\/wjsc.v15.i11.999"}],"container-title":["CNS Neuroscience &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cns.70357","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cns.70357","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cns.70357","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T15:04:52Z","timestamp":1773068692000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cns.70357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":58,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1111\/cns.70357"],"URL":"https:\/\/doi.org\/10.1111\/cns.70357","archive":["Portico"],"relation":{},"ISSN":["1755-5930","1755-5949"],"issn-type":[{"value":"1755-5930","type":"print"},{"value":"1755-5949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"2024-10-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70357"}}