{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T03:10:51Z","timestamp":1773112251576,"version":"3.50.1"},"reference-count":60,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271222"],"award-info":[{"award-number":["82271222"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007937","name":"Peking University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007937","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To analyze the effects of intravenous propofol combined with remifentanil on whole\u2010brain functional networks in patients with ischemic moyamoya disease (IMMD) and intraspinal space\u2010occupying lesions (SOLs) using resting\u2010state functional magnetic resonance imaging (rs\u2010fMRI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ten patients with IMMD and 10 sex\u2010 and age\u2010matched patients with lumbar SOL (normal cerebrovascular findings on preoperative MRI) were recruited. General anesthesia was administered using propofol and remifentanil. rs\u2010fMRI imaging was performed in both awake and anesthetized states. Whole\u2010brain functional network in different states was constructed based on graph theory tools.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In awake patients with IMMD, significant reductions in nodal strength (NS) were observed in the default mode network (DMN), sensorimotor network, and frontoparietal control network (FPN), compared to patients with SOL. Nodal efficiency (NE) showed further significant network declines. Under anesthesia, patients with IMMD: (1) exhibited disease\u2010specific decreases in NS and NE across several networks, potentially reflecting underlying cerebral pathology. (2) Propofol's effects also contributed to significant NS and NE reductions in several brain regions. Changes before and after anesthesia in patients with IMMD were significantly decreased in specific regions (discussed in detail) per analysis of NS versus NE. DMN connectivity correlated moderately with Montreal Cognitive Assessment scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Reduced whole\u2010brain functional connectivity in patients with IMMD before anesthesia was similar to the alterations caused by systemic intravenous drugs administered after anesthesia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>ChiCTR2300075268<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.70358","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T03:00:10Z","timestamp":1745982010000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Anesthesia on Brain Functional Networks in Moyamoya Disease and Spinal Lesions"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4969-7465","authenticated-orcid":false,"given":"Xuanling","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Peking University Third Hospital  Beijing China"},{"name":"Department of Anesthesiology Peking University International Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5261-8287","authenticated-orcid":false,"given":"Xuewei","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Peking University International Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengqian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Peking University Third Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengpei","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Brain Atlas and Brain\u2010Inspired Intelligence Institute of Automation, Chinese Academy of Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2467-9877","authenticated-orcid":false,"given":"Zhenhu","family":"Liang","sequence":"additional","affiliation":[{"name":"Institute of Electrical Engineering Yanshan University  Qinhuangdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Research Center Peking University Third Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Peking University International Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1359-5130","authenticated-orcid":false,"given":"Xiaoli","family":"Li","sequence":"additional","affiliation":[{"name":"The State Key Laboratory of Cognitive Neuroscience and Learning &amp; 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