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It is a major health issue affecting people of all age groups across the world, causing significant morbidity and mortality. TBI is a highly intricate disease process that causes both structural damage and functional deficits. These effects result from a combination of primary and secondary injury mechanisms. It is responsible for causing a range of negative effects, such as impairments in cognitive function, changes in social and behavioural patterns, difficulties with motor skills, feelings of anxiety, and symptoms of depression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>TBI associated various animal models were reviewed in databases including PubMed, Web of Science, and Google scholar etc. The current study provides a comprehensive overview of commonly utilized animal models for TBI and examines their potential usefulness in a clinical context.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Despite the notable advancements in TBI outcomes over the past two decades, there remain challenges in evaluating, treating, and addressing the long\u2010term effects and prevention of this condition. Utilizing experimental animal models is crucial for gaining insight into the development and progression of TBI, as it allows us to examine the biochemical impacts of TBI on brain mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This exploration can assist scientists in unraveling the intricate mechanisms involved in TBI and ultimately contribute to the advancement of successful treatments and interventions aimed at enhancing outcomes for TBI patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.70362","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T02:42:47Z","timestamp":1744857767000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Animal Models of Traumatic Brain Injury and Their Relevance in Clinical Settings"],"prefix":"10.1111","volume":"31","author":[{"given":"Payal","family":"Chauhan","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences Maharshi Dayanand University  Rohtak India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikita","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Maharshi Dayanand University  Rohtak India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karan","family":"Wadhwa","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Maharshi Dayanand University  Rohtak India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subbulakshmi","family":"Ganesan","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry School of Sciences, JAIN (Deemed to be University)  Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chakshu","family":"Walia","sequence":"additional","affiliation":[{"name":"Chandigarh Pharmacy College, Chandigarh Group of Colleges Jhanjheri  Mohali India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulshan","family":"Rathore","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics NIMS Institute of Pharmacy, NIMS University Rajasthan  Jaipur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Govind","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Maharshi Dayanand University  Rohtak India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mosleh Mohammad","family":"Abomughaid","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Sciences College of Applied Medical Sciences, University of Bisha  Bisha Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhilasha","family":"Ahlawat","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Maharshi Dayanand University  Rohtak India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2206-7236","authenticated-orcid":false,"given":"Athanasios","family":"Alexiou","sequence":"additional","affiliation":[{"name":"University Centre for Research &amp; 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