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Quantitative data, particularly pharmacokinetics, are scant, and direct evidence of the distribution of intranasally administered recombinant interleukin 10 (rIL\u201010) within the brain is lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Employing fluorescent labeling, in\u00a0vivo imaging, and confocal microscopy, we meticulously monitored the distribution and delivery pathways of intranasally administered rIL\u201010 in the brain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results and Conclusions<\/jats:title>\n                    <jats:p>Our findings demonstrate that rIL\u201010 can permeate the blood\u2013brain barrier and reach the perihematomal area in the striatum of mice with intracerebral hemorrhage. Intranasally administered rIL\u201010 primarily targets the cerebral cortex, striatum, and thalamus, traversing the olfactory nerve pathway and perivascular space to access these brain regions. This mode of delivery effectively mitigated secondary brain injury after intracerebral hemorrhage. This study contributes to intranasal drug delivery research, offering compelling evidence to support the intranasal delivery of anti\u2010inflammatory cytokines or alternative drug candidates for treating brain diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.70372","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T03:00:10Z","timestamp":1745982010000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Distribution of Intranasally Administered rIL\u201010 Along the Olfactory Nerve and Perivascular Space After Intracerebral Hemorrhage"],"prefix":"10.1111","volume":"31","author":[{"given":"Shaoshuai","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pain Medicine The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"},{"name":"Department of Human Anatomy, School of Basic Medical Sciences Zhengzhou University  Zhengzhou 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