{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:27:56Z","timestamp":1791912476381,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC3501304"],"award-info":[{"award-number":["2022YFC3501304"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271378"],"award-info":[{"award-number":["82271378"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Efgartigimod, a first\u2010in\u2010class neonatal Fc receptor antagonist, is approved for generalized myasthenia gravis (gMG). Its safety and efficacy across MG subtypes remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single\u2010center real\u2010world study (September 2023\u2013July 2024) analyzed patients from an MG registry study in China. The primary efficacy outcome is the mean MG\u2010ADL score changes from baseline at weeks 4, 8, and 12, analyzed via generalized estimating equations. Safety was assessed by adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 77 patients (mean age 56.1\u2009\u00b1\u200915.2\u2009years; 59.7% male), 76 completed at least one treatment cycle (20 completed 2\u2009cycles; 1 completed 3\u2009cycles). After efgartigimod treatment, MG\u2010ADL scores decreased significantly by week 4 (mean difference \u22126.4, 95% CI \u22127.2 to \u22125.6,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), sustaining through week 12 (\u22126.9, \u22127.8 to \u22126.1,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). After the second cycle, MG\u2010ADL scores at week 12 trended lower than the first cycle (mean difference: \u22120.8, 95% CI: \u22122.0 to \u22120.5,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.061). Efficacy was consistent across MGFA classes and thymoma status. In refractory patients, efgartigimod reduced MG\u2010ADL scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Adverse events occurred in 3.9% (3\/77).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Efgartigimod safely improved MG\u2010ADL scores and reduced steroid use across MG subtypes, with sustained efficacy through multiple treatment cycles. These findings support its potential when conventional therapies fail.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cns.70391","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T07:02:27Z","timestamp":1744786947000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Efficacy and Safety of Efgartigimod for Patients With Myasthenia Gravis in a Real\u2010World Cohort of 77 Patients"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7884-0438","authenticated-orcid":false,"given":"Sijia","family":"Hao","sequence":"first","affiliation":[{"name":"Department of Neurology, Tangdu Hospital The Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tangdu Hospital The Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongjing","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tangdu Hospital The Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tangdu Hospital The Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxi","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tangdu Hospital The Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tangdu Hospital The Fourth Military Medical University  Xi'an 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